Evidence map›Paper›PMID 31828505›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2020

Strain analysis reveals subtle systolic dysfunction in confirmed and suspected myocarditis with normal LVEF. A cardiac magnetic resonance study.

A Porcari, M Merlo, L Crosera, D Stolfo, G Barbati, F Biondi, G De Angelis, A Paldino, L Pagnan, M Belgrano and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Arrhythmic Phenotype in Cardiomyopathy.Heart failure clinics · 2022
    Review
  8. Review
  9. Article
  10. Re-introducing immunotherapy in patients surviving immune checkpoint inhibitors-mediated myocarditis.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

A PorcariCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.ORCID http://orcid.org/0000-0003-3307-0825
M MerloCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy. marco.merlo79@gmail.com.
L CroseraCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
D StolfoCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
G BarbatiDepartment of Medical Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy.
F BiondiCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
G De AngelisCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
A PaldinoCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
L PagnanDepartment of Radiology, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Trieste, Italy.
M BelgranoDepartment of Radiology, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Trieste, Italy.
M A CovaDepartment of Radiology, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Trieste, Italy.
B PinamontiCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
G VitrellaCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.
G SinagraCardiovascular Department, Azienda Sanitaria Universitaria Integrata of Trieste (ASUITs), University of Trieste, Via Pietro Valdoni 7, 34149, Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsLake Louise Criteria (LLC) are time-dependent and some acute myocarditis (AM) with preserved left ventricular ejection fraction (LVEF) could be missed, due to the limited accessibility of Cardiac Magnetic Resonance (CMR). We aimed to assess the potential value of cardiac strain measured by feature tracking (FT) imaging in this population. METHODS AND

resultsEighty-three patients with clinically suspected AM and normal LVEF were divided into 39 "confirmed AM" (positive LLC) and 44 "suspected AM" (negative LLC). An age and gender-matched sample of 42 normal subjects underwent CMR. In all groups, FT-derived biventricular strains and STE- global longitudinal strain (GLS) were assessed, being regularly measurable. Strain values < 5th percentile of the control group were considered abnormal. "Suspected" and "confirmed" AM were similar, except for medium time of CMR evaluation (5.2 vs 1 months from presentation, respectively; p = 0.004). Compared to healthy controls, both "suspected" and "confirmed" AM showed significantly impaired strain values. LV-global circumferential strain (GCS), right ventricular GCS and LV-GLS were abnormal in 15.4% and 15.9%, 20.5% and 15.9%, 7.7% and 9.1% in "confirmed" and "suspected" AM, respectively. STE analysis confirmed the results on LV-GLS, however a weak correlation emerged between STE and CMR-FT LV-GLS (p = 0.08).

conclusionsCompared to STE, CMR-FT analysis provided a more comprehensive and complementary biventricular strain evaluation that resulted similar in "confirmed" and "suspected" AM with normal LVEF. Conversely, mostly biventricular GCS was significantly reduced in up to 20% of patients, compared to healthy controls.

Indexed as

AdultCohort StudiesFemaleHumansMagnetic Resonance Imaging, CineMaleMiddle AgedMyocarditisPredictive Value of TestsRegistriesReproducibility of ResultsStroke VolumeVentricular Dysfunction, LeftYoung AdultCircumferential strainFeature tracking imagingLongitudinal strainMultiparametric approachMyocarditisNormal left-ventricular ejection fraction

Identifiers

PMID31828505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.