ArticleJournal of assisted reproduction and genetics2020
Ovarian stimulation is a safe and effective fertility preservation option in the adolescent and young adult population.
Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Ovarian stimulation and oocyte cryopreservation in females and transgender males aged 18 years or less: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Association of serum AMH levels with the number of oocytes retrieved in adolescent and young adult women undergoing controlled ovarian stimulation for fertility preservation.Archives of gynecology and obstetrics · 2025Article
- Clinical and ethical perspectives of ovarian stimulation and oocyte cryopreservation in adolescents: 6 years experience from a tertiary centre.Human reproduction open · 2025Article
- Reproductive Health in Women with Major β-Thalassemia: Evaluating Ovarian Reserve and Endocrine Complications.Metabolites · 2024Review
- Controlled ovarian stimulation in cancer patients under 18 years old; a case series.Journal of ovarian research · 2024Article
- A synopsis of global frontiers in fertility preservation.Journal of assisted reproduction and genetics · 2022Review
- Fertility preservation for pediatric patients with hemoglobinopathies: Multidisciplinary counseling needed to optimize outcomes.Frontiers in endocrinology · 2022Review
- Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults.Journal of clinical medicine · 2021Review
- Disparities in Female Pediatric, Adolescent and Young Adult Oncofertility: A Needs Assessment.Cancers · 2021Review
- Current Position of Oncofertility in Adolescent Female Cancer Patients: A Comparative Review on Society Guidelines.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe aim of this study is to describe the multidisciplinary approach and controlled ovarian hyperstimulation (COH) outcomes in adolescent and young adult (AYA) patients (ages 13-21) who underwent oocyte cryopreservation for fertility preservation (FP).
methodsMulti-site retrospective cohort was performed from 2007 to 2018 at Northwestern University and Michigan University. Data were analyzed by chi-square test, t-test, and logistic regression.
resultsForty-one patients began COH of which 38 patients successfully underwent oocyte retrieval, with mature oocytes obtained and cryopreserved without any adverse outcomes. To treat this group of patients, we use a multidisciplinary approach with a patient navigator. When dividing patients by ages 13-17 vs. 18-21, the median doses of FSH used were 2325 and 2038 IU, the median number of mature oocytes retrieved were 10 and 10, and median number frozen oocytes were 11 and 13, respectively. Median days of stimulation were 10 for both groups. There was no statistical difference in BMI, AMH, peak E
conclusionCOH with oocyte cryopreservation is a feasible FP option for AYAs who may not have other alternatives when appropriate precautions are taken, such as proper counseling and having a support team. These promising outcomes correspond to similar findings of recent small case series, providing hope for these patients to have genetically related offspring in the future.
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Registered trials
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