Trial reportEuropean journal of applied physiology2020
Prolonged cooling with phase change material enhances recovery and does not affect the subsequent repeated bout effect following exercise.
Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Short-duration phase-change material cryotherapy selectively enhances early neuromuscular and perceptual recovery.PloS one · 2026Trial
- Impact of different cryotherapy interventions on post-exercise acute delayed-onset muscle soreness, athletic performance, and inflammatory biomarkers: a systematic review and network meta-analysis.Frontiers in sports and active living · 2026Review
- Isolated and Combined Effects of Cold, Heat and Hypoxia Therapies on Muscle Recovery Following Exercise-Induced Muscle Damage.Sports medicine (Auckland, N.Z.) · 2025Review
- The isolated effects of local cold application on proteolytic and myogenic signaling.Cryobiology · 2023Article
- Cold for centuries: a brief history of cryotherapies to improve health, injury and post-exercise recovery.European journal of applied physiology · 2022Review
- Effect of cold and heat therapies on pain relief in patients with delayed onset muscle soreness: A network meta-analysis.Journal of rehabilitation medicine · 2022Article
- The cold truth: the role of cryotherapy in the treatment of injury and recovery from exercise.European journal of applied physiology · 2021Review
- Don't Lose Your Cool With Cryotherapy: The Application of Phase Change Material for Prolonged Cooling in Athletic Recovery and Beyond.Frontiers in sports and active living · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this investigation was twofold: (1) to examine the effect of prolonged phase change material (PCM) cooling following eccentric exercise of the quadriceps on indices of muscle damage, and (2) to elucidate whether application of PCM cooling blunted the acute adaptive response to eccentric exercise, known as the repeated bout effect (RBE).
methodsTwenty-six males (25 ± 6 years) performed an initial bout (B1) of 120 eccentric quadriceps contractions on each leg at 90% of their isometric strength and were then randomized to receive PCM packs frozen at 15 °C (treatment) or melted packs (control) worn directly on the skin under shorts for 6 h. The protocol was repeated 14 days later (B2) with all participants receiving the control condition.
resultsPCM cooling provided protection against strength loss in B1 (P = 0.005) with no difference in strength between treatment groups in B2 (P = 0.172; bout by treatment by time P = 0.008). PCM cooling reduced soreness in B1 (P = 0.009) with no difference between treatment groups in B2 (P = 0.061). Soreness was overall lower following B2 than B1 (P < 0.001). CK was elevated in B1 (P < 0.0001) and reduced in B2 (P < 0.001) with no difference between treatments. The damage protocol did not elevate hsCRP in B1, with no difference between treatments or between bouts.
conclusionsThis work provides further evidence that PCM cooling enhances recovery of strength and reduces soreness following eccentric exercise. Importantly, these data show for the first time that prolonged PCM cooling does not compromise the adaptive response associated with the RBE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.