Evidence map›Paper›PMID 31828475›Full record

Observational studyJournal of neurology2020

Cognitive dysfunction and brain atrophy in Susac syndrome.

Stéphanie Machado, Eric Jouvent, Isabelle Klein, François De Guio, Carla Machado, Fleur Cohen-Aubart, Karim Sacré, Thomas Papo

Registry-linked trialAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01481662 (Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01481662 unknown statusnot on this map

Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome (RETINOCOCHLEOCEREBRAL Vasculopathy)

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2011 to 2021Enrolled100ConditionsSUSAC's Syndrome, Encephalopathy, Hearing Loss, Retinal Artery Branch OcclusionsArmsDiffusion tensor magnetic resonance imaging of the brain
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. The neurocognitive and neuropsychiatric manifestations of Susac syndrome: a brief review of the literature and future directions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Stéphanie MachadoDepartment of Neurology, APHP, Lariboisière Hospital, F-75475, Paris, France.
Eric JouventDepartment of Neurology, APHP, Lariboisière Hospital, F-75475, Paris, France.ORCID http://orcid.org/0000-0001-7797-2236
Isabelle KleinDepartment of Radiology, Clinique Alleray-Labrouste, Paris, France.
François De GuioDepartment of Neurology, APHP, Lariboisière Hospital, F-75475, Paris, France.
Carla MachadoDepartment of Neurology, APHP, Lariboisière Hospital, F-75475, Paris, France.
Fleur Cohen-AubartDepartment of Internal Medicine, Sorbonne Université, APHP, Pitié-Salpétrière Hospital, Paris, France.
Karim SacréDepartment of Internal Medicine, APHP, Bichat Hospital, Paris, France.
Thomas PapoDepartment of Internal Medicine, APHP, Bichat Hospital, Paris, France. thomas.papo@aphp.fr.
Inserm · FRAssistance Publique – Hôpitaux de Paris · FRClinique Ambroise Paré · FRDélégation Paris 7 · FRSorbonne Université · FR

Funding

Ministère de l'Enseignement Supérieur et de la Recherche PHRC
6 · The paper itself

Abstract

backgroundSusac syndrome is a very rare cerebral small vessel disease, which can leave patients with cognitive impairment. We aimed at evaluating processing speed slowing, executive dysfunction and apathy and their relationships with whole brain and callosal atrophy.

methodsPatients with Susac syndrome included in a prospective observational cohort study were evaluated, while clinically steady-state, with standardized brain MRI and a neuropsychological battery specifically designed to capture minimal cognitive alterations in non-disabled young patients. Brain volume and corpus callosum area were measured using 3D-T1 sequences, repeatedly overtime. Relationships between neuropsychological data and brain volumetric measures obtained the same day were tested with linear regression while controlling for sex, age, level of education, scores of depression and of apathy.

resultsNineteen patients aged 37.5 ± 10.5 years were included. Mean follow-up time was 2.6 ± 1.3 years (5.8 ± 2.2 evaluations). While Montreal Cognitive Assessment scores were 25.1 ± 3.6, processing speed slowing was obvious (Trail Making Test version A: 43.1 ± 16.2 s; version B: 95.5 ± 67.9 s; reaction time: 314.6 ± 79.6 ms). Brain and corpus callosum atrophy was striking. No relationship was found between cognitive performances and brain volume or corpus callosum area.

conclusionPatients with Susac syndrome show largely preserved global cognitive functions but important processing speed alterations. Although brain and corpus callosum area atrophy is prominent and evolving, we did not find any relationship with cognitive alterations, questioning the mechanisms underlying cognitive alterations in these patients.

trial registrationClinical Trial Registration-URL: https://www.clinicaltrials.gov Unique Identifier: NCT01481662.

Indexed as

AdultApathyAtrophyBrainCognitive DysfunctionCorpus CallosumExecutive FunctionFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsProspective StudiesSusac SyndromeBrain atrophyCorpus callosumMild cognitive impairmentProcessing speed slowingSusac syndrome

Identifiers

PMID31828475
OpenAlexW2995991053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.