Observational studyPediatric nephrology (Berlin, Germany)2020
Prognostic role of acute kidney injury on long-term outcome in infants with hypoxic-ischemic encephalopathy.
Observational study in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05295784 (Pharmacokinetics), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Neonatal acute kidney injury: Reassessing diagnostic criteria for acute kidney injury in neonates with hypoxic-ischaemic encephalopathy undergoing therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal Acute Kidney Injury-An Australian and New Zealand Perspective.Journal of paediatrics and child health · 2026Review
- Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic-ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association between impaired renal function based on decline in serum creatinine level and brain injury in neonates with hypoxic-ischemic encephalopathy.Clinical and experimental pediatrics · 2026Article
- Early lactate elimination trend during therapeutic hypothermia predicts acute kidney injury in hypoxic ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Therapeutic hypothermia for neonates: a bibliometric analysis and visualization research.Frontiers in neurology · 2025Article
- Acute kidney injury during the first week of life: time for an update?Pediatric nephrology (Berlin, Germany) · 2024Article
- Acute kidney injury in neonates with hypoxic ischemic encephalopathy based on serum creatinine decline compared to KDIGO criteria.Pediatric nephrology (Berlin, Germany) · 2024Article
- Urine biomarkers of acute kidney injury and association with brain MRI abnormalities in neonatal hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Acute kidney injury in infants with hypoxic-ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2024Article
- Renal oximetry for early acute kidney injury detection in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Kidney outcomes in early adolescence following perinatal asphyxia and hypothermia-treated hypoxic-ischaemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2023Article
- Neonatal hypoxic ischemic encephalopathy increases acute kidney injury urinary biomarkers in a rat model.Physiological reports · 2022Article
- Neonatal Acute Kidney Injury.Frontiers in pediatrics · 2022Review
- Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage.Children (Basel, Switzerland) · 2021Article
- A single dose of aminophylline administration during therapeutic hypothermia; does it make a difference in glomerular filtration rate?European journal of pediatrics · 2021Article
- Creatinine Trends and Patterns in Neonates Undergoing Whole Body Hypothermia: A Systematic Review.Children (Basel, Switzerland) · 2021Review
- Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2021Observational
- Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia.Pediatric research · 2021Observational
- Renal Precision Medicine in Neonates and Acute Kidney Injury: How to Convert a Cloud of Creatinine Observations to Support Clinical Decisions.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to evaluate the prognostic role of postnatal acute kidney injury (AKI) on neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH).
methodsThis is a prospective observational study including all neonates with HIE receiving TH between 2009 and 2016 at a single center. AKI was classified according to the Kidney Disease: Improving Global Outcomes definition modified for neonatal age. Child development was assessed using the Griffiths Mental Development Scales (GMDS). Study outcome was defined as unfavorable outcome (including death or disability according to GMDS) or favorable otherwise, at 12 and 24 months.
resultsOne-hundred and one neonates (median gestational age 39 weeks) were included. AKI was diagnosed in 10 neonates (10%). Seven patients died within the first year, 35 patients had disability at 12 months, and 45 patients at 24 months. AKI was associated with increased likelihood of unfavorable outcome at 24 months (100% vs. 59% in neonates without AKI; p = 0.01). AKI showed good positive predictive value (1.00, 95% CI 0.71-1.00) and specificity (1.00, 95% CI 0.88-1.00), but poor negative predictive value (0.41, 95% CI 0.30-0.52) and sensitivity (0.19, 95% CI 0.11-0.32) at 24 months.
conclusionsAKI might be a reliable indicator of death or long-term disability in infants with HIE receiving TH, but the absence of AKI does not guarantee a favorable long-term outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.