Evidence map›Paper›PMID 31828354›Full record

ArticleWorld journal of urology2020

The evaluation of early predictive factors for urosepsis in patients with negative preoperative urine culture following mini-percutaneous nephrolithotomy.

Zewu Zhu, Yu Cui, Huimin Zeng, Yongchao Li, Feng Zeng, Yang Li, Zhiyong Chen, Chen Hequn

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Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

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3 · Its place in the literature

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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zewu ZhuDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yu CuiDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Huimin ZengDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yongchao LiDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Feng ZengDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Yang LiDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Zhiyong ChenDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Chen HequnDepartment of UrologyXiangya Hospital, Central South University, Changsha, 410008, Hunan, China. chenhequnxy@126.com.ORCID http://orcid.org/0000-0002-4286-9308
Central South University · CN

Funding

National Natural Science Foundation of China 81770705
6 · The paper itself

Abstract

purposeTo identify early predictive factors for urosepsis secondary to mini-percutaneous nephrolithotomy (MPCNL) in patients with negative preoperative urine culture (UC).

methodsA total of 786 patients with baseline negative UC who underwent MPCNL between January 2017 and June 2019 were retrospectively analyzed. Urosepsis was defined according to the Sepsis-3 definition. Subsequently, perioperative potential risk factors were compared between non-urosepsis and urosepsis groups.

resultsDespite negative UC in all patients, the rate of positive stone culture (SC) was 16.0%; the rate of pelvic urine culture (PUC) was 7.5%; 23 cases (2.9%) developed urosepsis after MPCNL. Univariate analysis showed that urosepsis was associated with the female gender, BMI, stone burden, diabetes mellitus and preoperative urine test. Multivariate logistic regression analysis suggested that urine test with positive nitrite and white blood cells and leukocyte esterase (N+WBC+LE+) (OR 17.51, 95% CI 6.75-45.38, P < 0.001) and operative time > 120 min (OR 3.53, 95% CI 1.41-8.85, P = 0.007) were independent risk factors for urosepsis. Additionally, receiver operating characteristic curve analysis of N+WBC+LE+ showed that the area under the curve was 0.785 for predicting the occurrence of urosepsis. Further analysis showed that N+WBC+LE+ provided an efficient prediction of SC+/PUC+ (SC+ or PUC+) with 61.7% sensitivity and 97.3% specificity.

conclusionsIn spite of the baseline negative preoperative UC, 2.9% of patients developed urosepsis after MPCNL. N+WBC+LE + was determined to be an early and efficient prediction of intraoperative bacterial status and urosepsis following MPCNL. Nevertheless, further studies are needed to confirm the results.

Indexed as

AdultAgedFemaleHumansKidney CalculiMaleMiddle AgedNephrolithotomy, PercutaneousPostoperative ComplicationsPredictive Value of TestsPreoperative PeriodRetrospective StudiesSepsisUrinalysisUrinary Tract InfectionsPercutaneous nephrolithotomyRenal stoneUrosepsis

Identifiers

PMID31828354
OpenAlexW2995313263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.