ArticleCerebral cortex (New York, N.Y. : 1991)2020
Cortical Surfaces Mediate the Relationship Between Polygenic Scores for Intelligence and General Intelligence.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.Translational psychiatry · 2026Article
- Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents.Behavior genetics · 2025Article
- Cortical Structure in Nodes of the Default Mode Network Estimates General Intelligence.Brain and behavior · 2025Article
- A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations.Nature. Mental health · 2024Article
- The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability.Genes, brain, and behavior · 2023Article
- Structural architecture and brain network efficiency link polygenic scores to intelligence.Human brain mapping · 2023Article
- Causal effects of cingulate morphology on executive functions in healthy young adults.Human brain mapping · 2022Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Genetic variation, brain, and intelligence differences.Molecular psychiatry · 2022Review
- Distinct Regionalization Patterns of Cortical Morphology are Associated with Cognitive Performance Across Different Domains.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults.Human brain mapping · 2021Article
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40 authors.
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Abstract
Recent large-scale, genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with general intelligence. The cumulative influence of these loci on brain structure is unknown. We examined if cortical morphology mediates the relationship between GWAS-derived polygenic scores for intelligence (PSi) and g-factor. Using the effect sizes from one of the largest GWAS meta-analysis on general intelligence to date, PSi were calculated among 10 P value thresholds. PSi were assessed for the association with g-factor performance, cortical thickness (CT), and surface area (SA) in two large imaging-genetics samples (IMAGEN N = 1651; IntegraMooDS N = 742). PSi explained up to 5.1% of the variance of g-factor in IMAGEN (F1,1640 = 12.2-94.3; P < 0.005), and up to 3.0% in IntegraMooDS (F1,725 = 10.0-21.0; P < 0.005). The association between polygenic scores and g-factor was partially mediated by SA and CT in prefrontal, anterior cingulate, insula, and medial temporal cortices in both samples (PFWER-corrected < 0.005). The variance explained by mediation was up to 0.75% in IMAGEN and 0.77% in IntegraMooDS. Our results provide evidence that cumulative genetic load influences g-factor via cortical structure. The consistency of our results across samples suggests that cortex morphology could be a novel potential biomarker for neurocognitive dysfunction that is among the most intractable psychiatric symptoms.
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