Evidence map›Paper›PMID 31828292›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2020

The Neural Basis for Response Latency in a Sensory-Motor Behavior.

Joonyeol Lee, Timothy R Darlington, Stephen G Lisberger

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Bioelectricity in dental medicine: a narrative review.Biomedical engineering online · 2024
    Review
  4. Article
  5. Article
  6. Latency correction in sparse neuronal spike trains.Journal of neuroscience methods · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joonyeol LeeCenter for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon 16419, Republic of Korea.
Timothy R DarlingtonDepartment of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Stephen G LisbergerDepartment of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Neural Control of Eye MovementR01EY027373 · NEI · DUKE UNIVERSITY · PI LISBERGER, STEPHEN G · 2017 to 2021
$2.6M
Visual-motor integration in smooth pursuit eye movementsF30EY027684 · NEI · DUKE UNIVERSITY · PI DARLINGTON, TIMOTHY · 2017 to 2020
$172k
NEI NIH HHS F30 EY027684NEI NIH HHS R01 EY027373NIGMS NIH HHS T32 GM007171
6 · The paper itself

Abstract

We seek a neural circuit explanation for sensory-motor reaction times. In the smooth eye movement region of the frontal eye fields (FEFSEM), the latencies of pairs of neurons show trial-by-trial correlations that cause trial-by-trial correlations in neural and behavioral latency. These correlations can account for two-third of the observed variation in behavioral latency. The amplitude of preparatory activity also could contribute, but the responses of many FEFSEM neurons fail to support predictions of the traditional "ramp-to-threshold" model. As a correlate of neural processing that determines reaction time, the local field potential in FEFSEM includes a brief wave in the 5-15-Hz frequency range that precedes pursuit initiation and whose phase is correlated with the latency of pursuit in individual trials. We suggest that the latency of the incoming visual motion signals combines with the state of preparatory activity to determine the latency of the transient response that controls eye movement. IMPACT STATEMENT: The motor cortex for smooth pursuit eye movements contributes to sensory-motor reaction time through the amplitude of preparatory activity and the latency of transient, visually driven responses.

Indexed as

AnimalsEye MovementsMacaca mulattaMaleMotor CortexNerve NetPhotic StimulationPsychomotor PerformanceReaction Timecorrelated variationfrontal eye fieldsmovement latencyneuron-behavior correlationssmooth pursuit eye movements

Identifiers

PMID31828292
PMCPMC7197090

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.