ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Longitudinal Association Between Perceived Fatigability and Cognitive Function in Older Adults: Results from the Baltimore Longitudinal Study of Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Twenty-year trends in cognitive performance and modifiable dementia risk factors: a Swiss population-based study.European journal of public health · 2026Article
- Mediating pathways of physical capabilities: linking perceived physical fatigability to motoric cognitive risk syndrome in community older adults.BMC geriatrics · 2026Article
- Psychometric properties of the Pittsburgh Fatigability Scale for assessing physical and mental fatigability in Brazilian older adults (PFS-Brasil).Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Paradox of life after work: A systematic review and meta-analysis on retirement anxiety and life satisfaction.PLOS global public health · 2024Article
- Measuring and Understanding the Health Impact of Greater Fatigability in Older Adults: A Call to Action and Opportunities.Fatigue : biomedicine, health & behavior · 2023Article
- Prospective Associations Between Physical Activity and Perceived Fatigability in Older Men: Differences by Activity Type and Baseline Marital Status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Association of leukocyte telomere length with perceived physical fatigability.Experimental gerontology · 2022Article
- Article
- Perceived Physical Fatigability Predicts All-Cause Mortality in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA).Journal of Alzheimer's disease : JAD · 2022Article
- Traits and treadmills: Association between personality and perceived fatigability in well-functioning community-dwelling older adults.Psychology and aging · 2021Article
- Association of Vision Impairment With Cognitive Decline Across Multiple Domains in Older Adults.JAMA network open · 2021Article
- Fatigability: A Prognostic Indicator of Phenotypic Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Relationship Between Personality Measures and Perceived Mental Fatigability.Journal of aging and healthArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive decline is consistently associated with diminished life satisfaction and inability to live independently. Identifying early, novel markers of cognitive decline is imperative for improving clinical detection and promoting long-term quality of life. Fatigability, one's perceived exertion after a standardized walking task, has been associated with declines in physical function; however, it remains unclear as to whether these effects may also extend to cognitive function.
methodsWe examined whether perceived fatigability, assessed as the rating of perceived exertion (RPE) after a 5 min slow-paced treadmill walk (0.67 m/s, 0% grade), is longitudinally associated with cognitive performance in the domains of memory, executive functions, language, and attention among 934 cognitively intact individuals aged at least 50 years participating in the Baltimore Longitudinal Study of Aging (BLSA); Mage = 69.6 ± 10.1, 51.9% female participants. Continuous associations between RPE and each domain (individual test and composite scores) were assessed using linear mixed-effect models adjusted for demographics and comorbid conditions.
resultsIn fully adjusted models, higher fatigability at baseline was associated with declines in all cognitive domains over an average 2.2 years of follow-up (p < .04 for all). Longitudinally, increased fatigability over time was associated with worsened executive functions (β= -0.01, p = .002).
conclusionsThese findings suggest that perceived fatigability after a standardized walking task may aid in identification of individuals at a higher risk of future cognitive decline. Future research should examine underlying biological mechanisms contributing to this relationship as well as whether future interventions may target fatigability in midlife to attenuate age-related cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.