Evidence map›Paper›PMID 31828240›Full record

ReviewTurkish journal of anaesthesiology and reanimation2019

Current Perspectives on Postoperative Cognitive Dysfunction in the Ageing Population.

Ivan Urits, Vwaire Orhurhu, Mark Jones, Dylan Hoyt, Allison Seats, Omar Viswanath

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Turkish journal of anaesthesiology and reanimation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05398757 (The Effect of Intraoperative Administration of Dexmedetomidine, Propofol and Midazolam on Postoperative Levels of Inflammatory Markers and Development of Postoperative Cognitive Dysfunction After Pertrochanteric Fracture Surgery.), which is not on this map. Cited by 39 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 5 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05398757 nawithdrawnnot on this mapstarted 2022, after this paper: background citation

The Effect of Intraoperative Administration of Dexmedetomidine, Propofol and Midazolam on Postoperative Levels of Inflammatory Markers and Development of Postoperative Cognitive Dysfunction After Pertrochanteric Fracture Surgery.

TypeinterventionalSponsorOsijek University HospitalRan2022 to 2024Enrolled0ConditionsPostoperative Cognitive Dysfunction, Postoperative Pain, Acute, Pertrochanteric FractureArmsMini mental state exame (MMSE), Digit Symbol Substitution Test (DSST), Numeric rating Scale (NRS), Postoperative inflammation, Midazolam
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  14. Evolving Concepts of Pain Management in Elderly Patients.Current pain and headache reports · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ivan UritsDepartment of Anaesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-3652-6085
Vwaire OrhurhuDepartment of Anaesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-2794-738X
Mark JonesDepartment of Anaesthesia, Critical Care, and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-4781-2167
Dylan HoytCreighton University School of Medicine - Phoenix Regional Campus, Phoenix, AZ, USA.ORCID https://orcid.org/0000-0001-9727-294X
Allison SeatsCreighton University School of Medicine - Phoenix Regional Campus, Phoenix, AZ, USA.ORCID https://orcid.org/0000-0001-9119-2172
Omar ViswanathValley Anaesthesiology and Pain Consultants, University of Arizona College of Medicine-Phoenix, Department of Anaesthesia, Phoenix, AZ, Creighton University School of Medicine, Department of Anesthesia, Omaha, NE, USA.ORCID https://orcid.org/0000-0002-6124-7037
Creighton University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative cognitive dysfunction (POCD) is defined as a prolonged cognitive function impairment that occurs within weeks to months of a surgical procedure. It is especially prevalent in the elderly population, leading to increased morbidity and mortality. As anaesthetic and surgical care continues to improve and become increasingly safer, a significantly greater number of older patients have elective surgical procedures today, yet this comes with an increased POCD risk as they go through the perioperative phases. Although the pathophysiology behind the development of POCD is still under investigation, current causative mechanisms include the mode of anaesthesia administered, anaesthetic used, cerebral hypoperfusion, hyperventilation and neuroinflammation. These findings lend an insight into the importance of being cognisant of the higher likelihood of POCD in at-risk patients, including the elderly, and taking precautions to include preoperative and postoperative cognitive testing, careful monitoring during anaesthesia, blood pressure control and early treatment of postoperative complications as they arise. In this review, we provide an update on the current understanding of the pathophysiology leading to POCD, identifying risk factors, prevention and treatment strategies, with a specific focus on the elderly population.

Indexed as

Ageinganaesthesiafrailtygeriatricspostoperative cognitive dysfunctionpostoperative delirium

Identifiers

PMID31828240
PMCPMC6886822
OpenAlexW2971412831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.