Evidence map›Paper›PMID 31828218›Full record

ArticleACS biomaterials science & engineering2018

Role of extracellular matrix in the biomechanical behavior of pancreatic tissue.

Alexa W Hudnut, Lian Lash-Rosenberg, An Xin, Juan A Leal Doblado, Cecilia Zurita-Lopez, Qiming Wang, Andrea M Armani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexa W HudnutDepartment of Biomedical Engineering, University of Southern California, 1002 Childs Way, MCB 495, Los Angeles, CA, 90089.
Lian Lash-RosenbergDepartment of Mechanical Engineering, University of Southern California, 1002 Childs Way, MCB 495, Los Angeles, CA, 90089.
An XinDepartment of Civil Engineering, University of Southern California, 920 Downey Way, BHE 222, Los Angeles, CA, 90089.
Juan A Leal DobladoDepartment of Chemistry and Biochemistry, California State University Los Angeles, 617 Charles E. Young Drive E, Room 251, Los Angeles, CA, 90095.
Cecilia Zurita-LopezDepartment of Chemistry and Biochemistry, California State University Los Angeles, 617 Charles E. Young Drive E, Room 251, Los Angeles, CA, 90095.
Qiming WangDepartment of Civil Engineering, University of Southern California, 920 Downey Way, BHE 222, Los Angeles, CA, 90089.
Andrea M ArmaniDepartment of Biomedical Engineering, University of Southern California, 1002 Childs Way, MCB 495, Los Angeles, CA, 90089.

Funding

Research Initiative for Scientific Enhancement (RISE)R25GM061331 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI FOSTER, KRISHNA L · 2000 to 2021
$33.1M
The Crosstalk Between Arginine Methylation and Serine Phosphorylation in Histone H3SC2GM118202 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI LOPEZ, CECILIA IRENE ZURITA · 2016 to 2018
$438k
NIGMS NIH HHS R25 GM061331NIGMS NIH HHS SC2 GM118202
6 · The paper itself

Abstract

Correlating the biomechanical properties of tissue with its function is an emerging area of research with potential impact in diagnostics, therapeutics, and prognostics. A critical stepping-stone in developing structure-function models is creating methods that can correlate the tissue structure with its mechanical behavior. As an initial step in addressing this challenge, we have characterized the mechanical behavior of unprocessed pancreatic tissue using optical fiber polarimetric elastography. To correlate the observed behavior to physiologically relevant structural features, a series of architectures are designed and fabricated using 3D printing. The mechanical response of the 3D printed elastomeric structures is analyzed using compressive testing and modeled using finite element analysis. The biomechanical behavior and buckling point of the 3D printed structures is used to create a calibration curve to understand the measured response of the resected pancreatic tissue. Based on the modeling and biomimetic results, the biomechanical behavior of pancreatic tissue is likely due to the collagen IV network.

Indexed as

3D printingBiomechanicsElastographyFEA modelingPolarimetryYoung’s modulus

Identifiers

PMID31828218
PMCPMC6905626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.