Evidence map›Paper›PMID 31828172›Full record

Trial reportJournal of immunology research2019

Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response.

Binfeng He, Mingdong Hu, Zhihui Liang, Qianli Ma, Yunhai Zi, Zhiwei Dong, Qi Li, Yongjun Luo, Guisheng Qian, Liang Guo and 3 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Binfeng HeInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.
Mingdong HuInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.
Zhihui LiangBethune International Peace Hospital of PLA, Shijiazhuang, Hebei 050000, China.
Qianli MaInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.ORCID https://orcid.org/0000-0003-4504-1933
Yunhai ZiInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.
Zhiwei DongCenter for Disease Control and Prevention of Zhengzhou City and First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
Qi LiInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.
Yongjun LuoCollege of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China.
Guisheng QianInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.
Liang GuoInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.
Kexiong LinDepartment of Respiration, Tongren City People's Hospital, Guizhou 554300, China.
Zhenyu LiuDepartment of Emergency, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.ORCID https://orcid.org/0000-0002-3207-1095
Guansong WangInstitute of Respiratory Diseases, Xinqiao Hospital of the Third Military Medical University, Chongqing 400037, China.ORCID https://orcid.org/0000-0002-5184-0777
Army Medical University · CNBethune International Peace Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNNanchang University · CNTongren Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a multicenter, double-blinded, randomized, placebo-controlled study. All subjects were at the same high altitude (3650 m) for 4-8 months before returning to lower altitudes. Subjects (

Indexed as

AcclimatizationAdolescentAdultAltitudeAnti-Inflammatory AgentsCapsulesCasein KinasesDouble-Blind MethodDrugs, Chinese HerbalGene ExpressionHumansHypoxiaInflammationInterleukin-10Interleukin-17L-Lactate DehydrogenaseAnti-Inflammatory AgentsCapsulesCasein KinasesDrugs, Chinese HerbalIL10 protein, humanIL17A protein, humanInterleukin-10Interleukin-17L-Lactate DehydrogenaseMicroRNAsMIRN155 microRNA, humanMIRN21 microRNA, humanOxygenshenqiTumor Necrosis Factor-alpha

Identifiers

PMID31828172
PMCPMC6881745
OpenAlexW2984811735

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.