Evidence map›Paper›PMID 31828115›Full record

ArticleBioMed research international2019

Excess Glutamate May Cause Dilation of Retinal Blood Vessels in Glutamate/Aspartate Transporter-Deficient Mice.

Takayuki Gonome, Yuting Xie, Saeko Arai, Kodai Yamauchi, Natsuki Maeda-Monai, Reiko Tanabu, Takashi Kudo, Mitsuru Nakazawa

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takayuki GonomeDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yuting XieDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Saeko AraiDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kodai YamauchiDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Natsuki Maeda-MonaiDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Reiko TanabuDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Takashi KudoDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Mitsuru NakazawaDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.ORCID https://orcid.org/0000-0001-6095-5712
Hirosaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the longitudinal findings of fundus features and spectral-domain optical coherence tomography (SD-OCT) to characterize the morphologic features in a mouse model of defective glutamate/aspartate transporter (GLAST MATERIALS AND

methodsThe fundus findings and SD-OCT images were longitudinally recorded at five time points from postnatal (P) 22 to P156 in GLAST

resultsThe retinal blood vessels appeared more dilated in GLAST DISCUSSION: In the present study, we found for the first time the dilation of the retinal blood vessels and the thinning of the ONL in GLAST

Indexed as

Amino Acid Transport System X-AGAnimalsDisease Models, AnimalElectroretinographyFundus OculiGlutamic AcidHumansMiceMice, KnockoutPhotoreceptor Cells, VertebrateRetinaRetinal DegenerationRetinal VesselsTomography, Optical CoherenceAmino Acid Transport System X-AGGlutamic Acid

Identifiers

PMID31828115
PMCPMC6881573
OpenAlexW2987556158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.