Evidence map›Paper›PMID 31828035›Full record

ReviewFrontiers in oncology2019

Biomarkers in Colorectal Cancer: The Role of Translational Proteomics Research.

Bruno Augusto Alves Martins, Gabriel Fonseca de Bulhões, Igor Norat Cavalcanti, Mickaella Michelson Martins, Paulo Gonçalves de Oliveira, Aline Maria Araújo Martins

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
  2. Research in pharmaceutical sciences · 2026
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  20. The Prognostic and Predictive Utility of CDX2 in Colorectal Cancer.International journal of molecular sciences · 2024
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bruno Augusto Alves MartinsMedical Sciences Postgraduate Program, School of Medicine, University of Brasilia, Brasília, Brazil.
Gabriel Fonseca de BulhõesUniCeub-Centro Universitário Do Distrito Federal, Translational Medicine Group, School of Medicine, Brasilia, Brazil.
Igor Norat CavalcantiUniCeub-Centro Universitário Do Distrito Federal, Translational Medicine Group, School of Medicine, Brasilia, Brazil.
Mickaella Michelson MartinsDepartment of Cell Biology, Institute of Biology, University of Brasilia, Brasilia, Brazil.
Paulo Gonçalves de OliveiraMedical Sciences Postgraduate Program, School of Medicine, University of Brasilia, Brasília, Brazil.
Aline Maria Araújo MartinsMedical Sciences Postgraduate Program, School of Medicine, University of Brasilia, Brasília, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is one of the most common cancers in the world, and it is one of the leading causes of cancer-related death. Despite recent progress in the development of screening programs and in the management of patients with colorectal cancer, there are still many gaps to fill, ranging from the prevention and early diagnosis to the determination of prognosis factors and treatment of metastatic disease, to establish a personalized approach. The genetic profile approach has been increasingly used in the decision-making process, especially in the choice of targeted therapies and in the prediction of drug response, but there are still few validated biomarkers of colorectal cancer for clinical practice. The discovery of non-invasive, sensitive, and specific biomarkers is an urgent need, and translational proteomics play a key role in this process, as they enable better comprehension of colorectal carcinogenesis, identification of potential markers, and subsequent validation. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through proteomics studies according to biomarker function and clinical application.

Indexed as

biomarkerscolorectal cancermass spectrometryproteomicstranslational research

Identifiers

PMID31828035
PMCPMC6890575

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.