ArticleSchizophrenia research. Cognition2020
Differential improvement of negative-symptom subfactors after cognitive remediation in low-functioning individuals with schizophrenia.
Article in Schizophrenia research. Cognition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cognitive function differences across subtypes of first-episode antipsychotic-naïve schizophrenia: insights from event-related potentials.European archives of psychiatry and clinical neuroscience · 2026Article
- Cognitive Correlates of Functional Disruption at Psychosis Onset: Unique Relevance of Visual Cognition.Journal of clinical medicine · 2025Article
- From Genetics to Psychosocial Functioning: Unraveling the Mediating Roles of Cognitive Reserve, Cognition, and Negative Symptoms in First-Episode Psychosis.Acta psychiatrica Scandinavica · 2025Article
- Anticholinergic load: A commonly neglected and preventable risk to cognition during schizophrenia treatment?Schizophrenia research. Cognition · 2024Article
- Cognitive Subtyping in Schizophrenia: A Latent Profile Analysis.Schizophrenia bulletin · 2021Article
- Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis.Frontiers in psychiatry · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundNegative symptoms and cognitive deficits have a substantial predictive value for functional deficits and recovery in schizophrenia. However, the relationship between negative symptoms and cognitive abnormalities is unclear possibly due to the heterogeneity of negative symptoms. This study used the model of expressive and experiential negative symptoms subfactors to decrease this heterogeneity. It examined these subfactors and cognition before and after treatment with computerized cognitive remediation training (CRT) in chronically-hospitalized individuals with psychosis and predominant negative symptoms.
methodsSeventy-eight adult participants with a DSM-IV-TR diagnosis of schizophrenia or schizoaffective disorder were enrolled in a 12-week CRT program. Assessments of demographic and illness variables, baseline and endpoint assessments of psychopathology (Positive and Negative Syndrome Scale) and cognition (MATRICS Consensus Cognitive Battery - MCCB) were conducted.
resultsThe baseline expressive negative subfactor was associated with Processing Speed (r = -0.352,
conclusionOur findings suggest that CRT has benefits for negative symptoms in very low-functioning patients and that this change may be in part mediated by change in cognitive functions after CRT.
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