ArticleRegenerative biomaterials2019
Comparative evaluation of the physicochemical properties of nano-hydroxyapatite/collagen and natural bone ceramic/collagen scaffolds and their osteogenesis-promoting effect on MC3T3-E1 cells.
Article in Regenerative biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Physicochemical Characterization of the Salmon Bone Hydroxyapatite and Collagen Mixture.Materials (Basel, Switzerland) · 2026Article
- Low frequency sinusoidal electromagnetic field accelerating intervertebral fusion through YAP/β-catenin axis.Stem cell research & therapy · 2026Article
- Article
- Composite barrier membrane for bone regeneration: advancing biomaterial strategies in defect repair.RSC advances · 2025Article
- Efficacy of a gelatin-based hemostatic sponge and hydroxyapatite-chitosan nanocomposites (nHAp/CS) on regeneration of radial bone defects in rabbits.Open veterinary journal · 2025Article
- Article
- Nano-hydroxyapatite/natural polymer composite scaffolds for bone tissue engineering: a brief review of recent trend.In vitro models · 2023Review
- Functionalized 3D-Printed PLA Biomimetic Scaffold for Repairing Critical-Size Bone Defects.Bioengineering (Basel, Switzerland) · 2023Article
- Magnesium (Mg2 +), Strontium (Sr2 +), and Zinc (Zn2 +) Co-substituted Bone Cements Based on Nano-hydroxyapatite/Monetite for Bone Regeneration.Biological trace element research · 2023Article
- Sustained release of brimonidine from polydimethylsiloxane-coating silicone rubber implant to reduce intraocular pressure in glaucoma.Regenerative biomaterials · 2023Article
- Scaffold-based bone tissue engineering in microgravity: potential, concerns and implications.NPJ microgravity · 2022Review
- Characterization of non-solvent- and thermal-induced phase separation applied polycaprolactone/demineralized bone matrix scaffold for bone tissue engineering.In vitro models · 2022Article
- Collagen/Nano-hydroxyapatite Composite Scaffold Application with Exchange Reamed Nailing Accelerates Bone Union and Improves Quality of Life in Atrophic Femoral Shaft Nonunions: A Retrospective Comparative Study.Indian journal of orthopaedics · 2022Article
- A Biomimetic Platelet-Rich Plasma-Based Interpenetrating Network Printable Hydrogel for Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications.BioImpacts : BI · 2022Article
- Angiogenic Potential of VEGF Mimetic Peptides for the Biofunctionalization of Collagen/Hydroxyapatite Composites.Biomolecules · 2021Article
- Wnt/Stem cells international · 2021Article
- Establishment of Collagen: Hydroxyapatite/BMP-2 Mimetic Peptide Composites.Materials (Basel, Switzerland) · 2020Article
- Review
- The Role of Marine Organic Extract in Bone Regeneration: A Pilot Study.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of various types of calcium phosphate has been reported in the preparation of repairing materials for bone defects. However, the physicochemical and biological properties among them might be vastly different. In this study, we prepared two types of calcium phosphates, nano-hydroxyapatite (nHA) and natural bone ceramic (NBC), into 3D scaffolds by mixing with type I collagen (CoL), resulting in the nHA/CoL and NBC/CoL scaffolds. We then evaluated and compared the physicochemical and biological properties of these two calcium phosphates and their composite scaffold with CoL. Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy (XRD) and compressive tests were used to, respectively, characterize the morphology, composition, distribution and the effect of nHA and NBC to collagen. Next, we examined the biological properties of the scaffolds using cytotoxicity testing, flow cytometry, immunofluorescence staining, biocompatibility testing, CCK-8 assays and RT-PCR. The results reflected that the Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.