Evidence map›Paper›PMID 31827715›Full record

ArticleOxidative medicine and cellular longevity2019

Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress.

Xuehua Piao, Yanping Zou, Xiaodan Sui, Baohai Liu, Fanji Meng, Shuangdi Li, Qingyu Zhang, Chi Ma, Tong Wu

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xuehua PiaoDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.ORCID https://orcid.org/0000-0003-3310-4183
Yanping ZouDepartment of Digestive Endoscopy, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.
Xiaodan SuiInternal Medicine of Traditional Chinese Medicine, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.
Baohai LiuDepartment of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.ORCID https://orcid.org/0000-0003-0906-0379
Fanji MengDepartment of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Shuangdi LiHeart Disease Center, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China.
Qingyu ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.
Chi MaDepartment of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.
Tong WuDepartment of Gastroenterology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.
Jinzhou Medical University · CNChangchun University of Chinese Medicine · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrostatin-SN1 (peptide sequence, DEQHLETELHTLTSVLTANGFQ), a kind of peptides extracted from snake venom, has been reported to have anti-inflammatory effect, but its truncated mutant hydrostatin-SN10 (peptide sequence, DEQHLETELH) on pancreatitis-induced acute lung injury has not been well documented. Interleukin- (IL-) 6-induced Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) pathway is involved with inflammatory and oxidative stress activities and may be associated with the pathogenesis of lung injury, and related molecules were measured. Taurocholate-induced pancreatitis associated with acute lung injury was established and treated with hydrostatin-SN10. Pancreatitis was confirmed by measuring the serum levels of amylase, lipase, and trypsinogen and urinary amylase. Lung injury was determined by histologically assessing acinar cell changes. The related molecules of IL-6-induced JAK2/STAT3-associated inflammation and oxidative stress were quantitated by real time-PCR, Western blot, and/or immunochemical assay. Hydrostatin-SN10 reduced the levels of serum amylase, lipase, and trypsinogen and urinary amylase when compared with the model group (

Indexed as

Acute Lung InjuryAnimalsCholagogues and CholereticsElapid VenomsGene Expression RegulationInflammationInterleukin-6Janus Kinase 2MaleMice, Inbred C57BLMutationOxidative StressPancreatitisPeptide FragmentsSTAT3 Transcription FactorTaurocholic AcidCholagogues and CholereticsElapid VenomsInterleukin-6interleukin-6, mouseJak2 protein, mouseJanus Kinase 2Peptide FragmentsStat3 protein, mouseSTAT3 Transcription FactorTaurocholic Acid

Identifiers

PMID31827715
PMCPMC6885838
OpenAlexW2988376530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.