Evidence map›Paper›PMID 31827650›Full record

ArticleDisease markers2019

Valuable Serum Markers in Pulmonary Alveolar Proteinosis.

Shenyun Shi, Lulu Chen, Xiaohua Qiu, Qi Zhao, Yonglong Xiao, Xin Yan

Abstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Alveolar proteinosis due to toxic inhalation at workplace.Respiratory medicine case reports · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shenyun ShiDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008 Jiangsu, China.ORCID https://orcid.org/0000-0002-2022-121X
Lulu ChenDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.ORCID https://orcid.org/0000-0002-2020-863X
Xiaohua QiuDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.ORCID https://orcid.org/0000-0001-6348-1348
Qi ZhaoDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.ORCID https://orcid.org/0000-0002-6749-6835
Yonglong XiaoDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.ORCID https://orcid.org/0000-0003-1194-1394
Xin YanDepartment of Respiratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.ORCID https://orcid.org/0000-0002-2829-3277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSeveral serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort.

methodsPAP patients from January 2010 to June 2018 were enrolled. Hospital records were used as data sources. The levels of various serum indicators were detected. We evaluated the correlation between pulmonary function test results and clinical variables.

resultsDiffusion capacity for carbon monoxide (DLCO) level was positively correlated with the level of high-density lipoprotein cholesterol (HDL-C) (

conclusionsSerum CEA, CYFRA21-1, and LDH are valuable serum markers for the evaluation of disease activity of PAP and may predict the response to treatment of PAP.

Indexed as

AdultAntigens, NeoplasmBiomarkersCarbon MonoxideCarcinoembryonic AntigenCholesterol, HDLFemaleFollow-Up StudiesGPI-Linked ProteinsGranulocyte-Macrophage Colony-Stimulating FactorHumansKeratin-19MaleMiddle AgedPhosphopyruvate HydratasePrognosisantigen CYFRA21.1Antigens, NeoplasmBiomarkersCarbon MonoxideCarcinoembryonic AntigenCEACAM5 protein, humanCholesterol, HDLGPI-Linked ProteinsGranulocyte-Macrophage Colony-Stimulating FactorKeratin-19Phosphopyruvate Hydratase

Identifiers

PMID31827650
PMCPMC6885220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.