Evidence map›Paper›PMID 31827639›Full record

ArticleDisease markers2019

Altered Gut Microbiota Diversity and Composition in Chronic Urticaria.

Tao Lu, Yanxia Chen, Yangmin Guo, Jiayu Sun, Weitao Shen, Mengsi Yuan, Shuping Zhang, Ping He, Xiaoyang Jiao

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Blastocystis, urticaria, and skin disorders: review of the current evidences.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Pooled it
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  13. The curious case ofGut microbes · 2023
    Review
  14. Association of GutLife (Basel, Switzerland) · 2023
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tao LuThe First Affiliated Hospital of Shantou University Medical College, China.ORCID https://orcid.org/0000-0002-9580-0451
Yanxia ChenThe First Affiliated Hospital of Shantou University Medical College, China.
Yangmin GuoThe First Affiliated Hospital of Shantou University Medical College, China.
Jiayu SunBiology and Genetic Department of Shantou University Medical College, China.
Weitao ShenThe Second Affiliated Hospital of Shantou University Medical College, China.
Mengsi YuanThe First Affiliated Hospital of Shantou University Medical College, China.
Shuping ZhangThe First Affiliated Hospital of Shantou University Medical College, China.ORCID https://orcid.org/0000-0003-3556-9558
Ping HeBiology and Genetic Department of Shantou University Medical College, China.
Xiaoyang JiaoBiology and Genetic Department of Shantou University Medical College, China.ORCID https://orcid.org/0000-0002-7568-0595
Shantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathogenesis of chronic urticaria (CU) is closely related to imbalances in immunity. The gastrointestinal microflora provides a vast and continuous stimulation for the immune system. However, the composition and diversity of gut microflora in CU patients are rarely reported.

methods10 CU patients and 10 healthy individuals were selected in this study, and their intestinal microbiome was detected by 16S rRNA sequencing. The data were analyzed using R language software.

results392 bacterial OTUs were common in the CU and healthy groups, but there were 159 OTUs particularly existing in the CU group, while 87 OTUs only were observed in healthy individuals. The bacterial diversity was reduced in CU patients compared with healthy individuals. The principal component analysis (PCA) and principal coordinate analysis (PCoA) revealed that the bacterial cluster in CU patients and the healthy controls were divided into different branches. Pathogenic strains including

conclusionOur results demonstrated that the microbial composition was significantly different between CU patients and the healthy individual, which may be the reason leading to the various outcomes of probiotic treatment.

Indexed as

BiodiversityGastrointestinal MicrobiomeAdolescentAdultBacteriaCase-Control StudiesChildChinaChronic UrticariaFecesFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRNA, Ribosomal, 16S

Identifiers

PMID31827639
PMCPMC6881578
OpenAlexW2984279952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.