Evidence map›Paper›PMID 31827632›Full record

ArticleDisease markers2019

Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance.

Liangwei Yang, Yu Yu, Xiuchong Yu, Jiaming Zhou, Zhiping Zhang, Shibo Ying, Junming Guo, Zhilong Yan

Abstract read
In one paragraph

Article in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liangwei YangMedical School of Ningbo University, Ningbo No. 1 Hospital, Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China.ORCID https://orcid.org/0000-0001-7389-4031
Yu YuMedical School of Ningbo University, Ningbo No. 1 Hospital, Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China.ORCID https://orcid.org/0000-0003-2562-009X
Xiuchong YuMedical School of Ningbo University, Ningbo No. 1 Hospital, Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China.ORCID https://orcid.org/0000-0003-2691-7899
Jiaming ZhouMedical School of Ningbo University, Ningbo No. 1 Hospital, Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China.ORCID https://orcid.org/0000-0001-9411-0777
Zhiping ZhangDepartment of Gastrointestinal Surgery, Ningbo No. 1 Hospital, Ningbo 315010, China.ORCID https://orcid.org/0000-0003-3483-0195
Shibo YingInstitute of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.ORCID https://orcid.org/0000-0001-5275-9383
Junming GuoMedical School of Ningbo University, Ningbo No. 1 Hospital, Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China.ORCID https://orcid.org/0000-0003-2026-1075
Zhilong YanDepartment of Gastrointestinal Surgery, Ningbo No. 1 Hospital, Ningbo 315010, China.ORCID https://orcid.org/0000-0001-5898-3650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) has a poor prognosis due to the lack of ideal tumor markers. Circular RNAs (circRNAs) are a novel type of noncoding RNA related to the occurrence of GC. Among our research, we investigated the role of hsa_circ_0005556 in GC. MATERIALS AND

methodsThe expression of hsa_circ_0005556 of 100 paired GC tissues and adjacent normal tissues was detected using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was established to evaluate the diagnostic value of hsa_circ_0005556. The correlation between the expression of hsa_circ_0005556 and corresponding clinicopathological characteristic was explored.

resultshsa_circ_0005556 was significantly downregulated in GC tissues contrasted with adjacent normal tissues (

conclusionhsa_circ_0005556 is a potential biomarker for GC, which may guide judgment of the indication of endoscopic treatment for early gastric cancer (EGC).

Indexed as

Gene Expression Regulation, NeoplasticAdenocarcinomaBiomarkers, TumorCase-Control StudiesDown-RegulationFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessPrognosisRNA, CircularStomach NeoplasmsSurvival RateBiomarkers, TumorRNA, Circular

Identifiers

PMID31827632
PMCPMC6885797

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.