Evidence map›Paper›PMID 31827526›Full record

ArticleStem cells international2019

Adipose-Derived Stem Cell Transplantation Attenuates Inflammation and Promotes Liver Regeneration after Ischemia-Reperfusion and Hemihepatectomy in Swine.

Zhihui Jiao, Yajun Ma, Xiaoning Liu, Yansong Ge, Qianzhen Zhang, Boyang Liu, Hongbin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  8. Editorial: MSC-derived exosomes in tissue regeneration.Frontiers in cell and developmental biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhihui JiaoDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID https://orcid.org/0000-0001-7055-3485
Yajun MaDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Xiaoning LiuDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Yansong GeDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Qianzhen ZhangDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Boyang LiuDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
Hongbin WangDepartment of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.ORCID https://orcid.org/0000-0002-4454-3328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the anti-inflammatory and liver regenerative effects of adipose-derived mesenchymal stem cells (ADSCs) on a porcine model of ischemia-reperfusion (IR) and hemihepatectomy.

methodsEighteen healthy Bama miniature pigs were randomly divided into the sham-operated (sham), untreated IR injury (IRI), and ADSC-transplanted (ADSC) groups. Hepatic IR was established by laparoscopic hemihepatectomy. ADSCs were transplanted directly into the liver parenchyma after the surgery. Hepatic inflammation and liver regeneration were evaluated by histopathological examination and assessment of relevant cytokines and other factors.

resultsADSC transplantation successfully ameliorated the IRI-induced histopathological damage and the high levels of pro-inflammatory cytokines like IL-1

conclusionsADSCs attenuated the hepatic IRI-induced inflammatory response and promoted liver regeneration.

Identifiers

PMID31827526
PMCPMC6885808

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.