Evidence map›Paper›PMID 31827475›Full record

ReviewFrontiers in immunology2019

The Evolution of T Cell Depleted Haploidentical Transplantation.

Franco Aversa, Antonio Pierini, Loredana Ruggeri, Massimo Fabrizio Martelli, Andrea Velardi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
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  4. Stem cell transplantation for ALL: you've always got a donor, why not always use it?Hematology. American Society of Hematology. Education Program · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Franco AversaHematology and Bone Marrow Transplantation Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Antonio PieriniDivision of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
Loredana RuggeriDivision of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
Massimo Fabrizio MartelliDivision of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
Andrea VelardiDivision of Hematology and Clinical Immunology, Department of Medicine, University of Perugia, Perugia, Italy.
University of Perugia · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Work on bone marrow transplantation from haploidentical donor has been proceeding for over 20 years all over the world and new transplant procedures have been developed. To control both graft rejection and graft vs. host disease, some centers have preferred to enhance the intensity of the conditioning regimens and the post-transplant immune suppression in the absence of graft manipulation; others have concentrated on manipulating the graft in the absence of any additional post-transplant immune suppressive agent. Due to the current high engraftment rates, the low incidence of graft-vs.-host disease and regimen related mortality, transplantation from haploidentical donors have been progressively offered even to elderly patients. Overall, survivals compare favorably with reports on transplants from unrelated donors. Further improvements will come with successful implementation of strategies to enhance post-transplant immune reconstitution and to prevent leukemia relapse.

Indexed as

Transplantation, HaploidenticalAnimalsBone Marrow TransplantationGraft vs Host DiseaseHumansLeukemiaT-Lymphocytesgraft vs. host diseasegraft vs. leukemia effecthaploidentical transplantationimmune reconstitutionT cell depletion

Identifiers

PMID31827475
PMCPMC6890606
OpenAlexW2989797048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.