Evidence map›Paper›PMID 31827470›Full record

Trial reportFrontiers in immunology2019

Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells.

Leigh Fisher, Melissa Zinter, Sherry Stanfield-Oakley, Lindsay N Carpp, R Whitney Edwards, Thomas Denny, Zoe Moodie, Fatima Laher, Linda-Gail Bekker, M Juliana McElrath and 5 more

Open access · goldAbstract readClinical Trial, Phase IClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Leigh FisherVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Melissa ZinterDepartment of Surgery, Duke University Medical Center, Durham, NC, United States.
Sherry Stanfield-OakleyDepartment of Surgery, Duke University Medical Center, Durham, NC, United States.
Lindsay N CarppVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
R Whitney EdwardsDepartment of Surgery, Duke University Medical Center, Durham, NC, United States.
Thomas DennyDuke University Medical Center, Duke Human Vaccine Institute, Durham, NC, United States.
Zoe MoodieVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Fatima LaherPerinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Soweto, South Africa.
Linda-Gail BekkerThe Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
M Juliana McElrathVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Peter B GilbertVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Lawrence CoreyVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Georgia TomarasDepartment of Surgery, Duke University Medical Center, Durham, NC, United States.
Justin PollaraDepartment of Surgery, Duke University Medical Center, Durham, NC, United States.
Guido FerrariDepartment of Surgery, Duke University Medical Center, Durham, NC, United States.
Duke Medical Center · USFred Hutch Cancer Center · USDuke University Hospital · USPerinatal HIV Research Unit · ZAUniversity of Cape Town · ZA

Funding

LOC: HIV Vaccine Trials NetworkUM1AI068614 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Dan H. Barouch, Lawrence Corey · 2011 to 2026
$1175.6M
LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Soweto Clinical Trials UnitUM1AI069453 · NIAID · WITS HEALTH CONSORTIUM (PTY), LTD · PI Glenda E Gray, Lerato Mohapi · 2012 to 2026
$40.9M
South African Medical Research Council Clinical Trials Unit (MRC CTU)UM1AI069422 · NIAID · MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA · PI ABDULLAH, MAHOMED FAREED ABOOBAKER, GOGA, AMEENA · 2012 to 2020
$37.4M
University of KwaZulu-Natal - CAPRISA HIV/AIDS Clinical Trials UnitUM1AI069469 · NIAID · UNIVERSITY OF KWAZULU-NATAL · PI QUARRAISHA ABDOOL KARIM · 2012 to 2026
$36.4M
University of Cape Town Clinical Trials Unit (UCTCTU)UM1AI069519 · NIAID · UNIVERSITY OF CAPE TOWN · PI Linda-Gail Bekker · 2012 to 2026
$36.3M
Physical Resources CoreP01AI120756 · NIAID · DUKE UNIVERSITY · PI TOMARAS, GEORGIA DORIS · 2016 to 2020
$17.1M
Combined Hepatitis B and HIV-1 envelope vaccination to augment T cell help via linked recognition of unrelated antigensK01OD024877 · OD · DUKE UNIVERSITY · PI POLLARA, JUSTIN JOSEPH · 2017 to 2019
$1.0M
Regulation of HLA-C in Human Trophoblasts and its Impact on Preterm BirthR21AI138019 · NIAID · HARVARD UNIVERSITY · PI STROMINGER, JACK L · 2019 to 2020
$465k
Dual-Affinity Re-Targeting Proteins for Cure of Newborn Infant HIV-1 InfectionR21AI127022 · NIAID · DUKE UNIVERSITY · PI POLLARA, JUSTIN JOSEPH · 2016 to 2017
$437k
NIAID NIH HHS HHSN272201000045CNIAID NIH HHS HHSN272201700061CNIAID NIH HHS P01 AI120756NIAID NIH HHS P30 AI064518NIAID NIH HHS R21 AI127022NIAID NIH HHS R21 AI138019NIAID NIH HHS UM1 AI068614NIAID NIH HHS UM1 AI068618NIAID NIH HHS UM1 AI068635NIAID NIH HHS UM1 AI069422NIAID NIH HHS UM1 AI069453NIAID NIH HHS UM1 AI069469NIAID NIH HHS UM1 AI069519NIH HHS K01 OD024877NIMH NIH HHS R21 MH083308
6 · The paper itself

Abstract

The secondary analyses for correlates of risk of infection in the RV144 HIV-1 vaccine trial implicated vaccine-induced antibody-dependent cellular cytotoxicity (ADCC) responses in the observed protection, highlighting the importance of assessing such responses in ongoing and future HIV-1 vaccine trials. However,

Indexed as

Antibody-Dependent Cell CytotoxicityAdultAIDS VaccinesFemaleGranzymesHIV-1HIV AntibodiesHIV InfectionsHumansInterleukin-15Killer Cells, NaturalMaleYoung AdultAIDS VaccinesGranzymesHIV AntibodiesInterleukin-15antibody-dependent cellular cytotoxicityHIV-1 infectious molecular clone-infected target cell assayHIV vaccine trialinterleukin-15natural killer cells

Identifiers

PMID31827470
PMCPMC6890556
OpenAlexW2990676987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.