ArticleFrontiers in psychology2019
The Differential Role of Central and Bridge Symptoms in Deactivating Psychopathological Networks.
Article in Frontiers in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed.
- Associations between sexual minority and intraminority stressors and thinness- and muscularity-oriented eating and body image disturbances in sexual minoritized men: Variable-centered, person-centered, and network analyses.Eating and weight disorders : EWD · 2026Article
- Anxiety-depression symptom networks across emotion regulation profiles in Chinese nurses: a latent profile and network analysis.BMC nursing · 2026Article
- Network-guided symptom targets in maintenance hemodialysis using in silico interventions: a multicenter cross-sectional study.BMC nephrology · 2026Observational
- Associations between PTSD and psychotic symptoms: A network analysis of patients with psychotic disorders in Uganda: Psychosis-PTSD network analysis.SSM. Mental health · 2026Article
- A population-based cross-lagged panel network analysis of multidimensional mental health symptoms among Chinese secondary school students.BMC public health · 2026Article
- Occupational stress, burnout, and depression: an exploration from a network analysis perspective.Psychological medicine · 2026Article
- Identifying symptom communities and core symptoms in the anxiety-depression network among computer science students.Scientific reports · 2026Article
- From childhood maltreatment to depression and anxiety: a network approach focusing on perceived emotional invalidation.BMC psychology · 2026Article
- Malnutrition-related symptom clusters and quality of life in nasopharyngeal carcinoma patients during radiotherapy: a network analysis.BMC cancer · 2026Article
- Network Analysis of Multidimensional Interactions Between Self-Regulatory Fatigue, Decision Conflict, and Quality of Life in Advanced Cancer Patients: Identifying Core Nodes for Precision Intervention.Healthcare (Basel, Switzerland) · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- A Network Analysis of Inner Strength Among University Students with Borderline Personality Disorder Symptoms.European journal of investigation in health, psychology and education · 2026Article
- The relationship between sport motivation and problematic social networking sites use among adolescents: a study integrating mediation modeling and network analysis.Frontiers in psychology · 2026Article
- Relationship between cognitive function, oral health, and activities of daily living among older adults in the context of rural China: a network analysis approach.Frontiers in public health · 2026Article
- Core Symptoms and Candidate Targets for Symptom Management in Late Pregnancy: A Network Analysis.Journal of multidisciplinary healthcare · 2026Article
- A Latent profile and network intervention analysis of psychosomatic symptoms in lung cancer immunotherapy patients.PloS one · 2026Article
- Identifying Core Joint Attention Behaviors and Exploring Pathways to Autistic Traits in School-Aged Children With Autism Spectrum Disorder: A Network Analysis Study.Journal of autism and developmental disorders · 2025Article
- Network analysis of multidimensional symptom experience among postoperative esophageal cancer survivors.Health and quality of life outcomes · 2025Article
- Network analysis of fatigue symptoms in Chinese patients with advanced cancer.Asia-Pacific journal of oncology nursing · 2025Article
- Symptoms experience during the oral intake rehabilitation period following esophagectomy: A network analysis.Asia-Pacific journal of oncology nursing · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The network model of psychopathology suggests that central and bridge symptoms represent promising treatment targets because they may accelerate the deactivation of the network of interactions between the symptoms of mental disorders. However, the evidence confirming this hypothesis is scarce. This study re-analyzed a convenience sample of 51 cross-sectional psychopathological networks published in previous studies addressing diverse mental disorders or clinically relevant problems. In order to address the hypothesis that central and bridge symptoms are valuable treatment targets, this study simulated five distinct attack conditions on the psychopathological networks by deactivating symptoms based on two characteristics of central symptoms (degree and strength), two characteristics of bridge symptoms (overlap and bridgeness), and at random. The differential impact of the characteristics of these symptoms was assessed in terms of the magnitude and the extent of the attack required to achieve a maximum impact on the number of components, average path length, and connectivity. Only moderate evidence was obtained to sustain the hypothesis that central and bridge symptoms constitute preferential treatment targets. The results suggest that the degree, strength, and bridgeness attack conditions are more effective than the random attack condition only in increasing the number of components of the psychopathological networks. The degree attack condition seemed to perform better than the strength, bridgeness, and overlap attack conditions. Overlapping symptoms evidenced limited impact on the psychopathological networks. The need to address the basic mechanisms underlying the structure and dynamics of psychopathological networks through the expansion of the current methodological framework and its consolidation in more robust theories is stressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.