Evidence map›Paper›PMID 31827438›Full record

ArticleFrontiers in pharmacology2019

The Antimalarial Chloroquine Reduces the Burden of Persistent Atrial Fibrillation.

Catalina Tobón, Laura C Palacio, Bojjibabu Chidipi, Diana P Slough, Thanh Tran, Nhi Tran, Michelle Reiser, Yu-Shan Lin, Bengt Herweg, Dany Sayad and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Bioengineered peptibodies as blockers of ion channels.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. IiScience · 2022
    Article
  5. Review
  6. Review
  7. Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia.The Journal of innovations in cardiac rhythm management · 2020
    Review
  8. Cardiac effects and toxicity of chloroquine: a short update.International journal of antimicrobial agents · 2020
    Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Catalina TobónMATBIOM, Universidad de Medellín, Medellín, Colombia.
Laura C PalacioMATBIOM, Universidad de Medellín, Medellín, Colombia.
Bojjibabu ChidipiMolecular Pharmacology and Physiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Diana P SloughDepartment of Chemistry, Tufts University, Medford, MA, United States.
Thanh TranCardiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Nhi TranCardiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Michelle ReiserMolecular Pharmacology and Physiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Yu-Shan LinDepartment of Chemistry, Tufts University, Medford, MA, United States.
Bengt HerwegCardiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Dany SayadCardiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Javier SaizCi2 B, Universitat Politècnica de València, Valencia, Spain.
Sami NoujaimMolecular Pharmacology and Physiology Department, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
University of South Florida · USTufts University · USUniversidad de Medellín · COUniversitat Politècnica de València · ES

Funding

Molecular Mechanisms for Atrial Fibrillation in AgingR01HL129136 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2015 to 2019
$2.0M
Bioengineered peptibodies as antiarrhythmic therapy in atrial fibrillationR21HL138064 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2017 to 2018
$411k
NHLBI NIH HHS R01 HL129136NHLBI NIH HHS R21 HL138064
6 · The paper itself

Abstract

In clinical practice, reducing the burden of persistent atrial fibrillation by pharmacological means is challenging. We explored if blocking the background and the acetylcholine-activated inward rectifier potassium currents (I

Indexed as

chloroquineIK1IKAChpersistent atrial fibrillationpotassium inward rectifiers

Identifiers

PMID31827438
PMCPMC6890839
OpenAlexW2990102915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.