Evidence map›Paper›PMID 31827415›Full record

ArticleDose-response : a publication of International Hormesis Society

Proteomic Analysis of Radiation-Induced Acute Liver Damage in a Rabbit Model.

Lingong Jiang, Huimin Jia, Zhicheng Tang, Xiaofei Zhu, Yangsen Cao, Yin Tang, Haiyan Yu, Jianping Cao, Huojun Zhang, Shuyu Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. mCell death and differentiation · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lingong JiangDepartment of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0000-0002-6214-2069
Huimin JiaSchool of Radiation Medicine and Protection and State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China.
Zhicheng TangSchool of Radiation Medicine and Protection and State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China.
Xiaofei ZhuDepartment of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yangsen CaoDepartment of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yin TangDepartment of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Haiyan YuDepartment of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Jianping CaoSchool of Radiation Medicine and Protection and State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China.
Huojun ZhangDepartment of Radiation Oncology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Shuyu ZhangSchool of Radiation Medicine and Protection and State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0003-1419-3635
Second Military Medical University · CNSoochow University · CNChina National Nuclear Corporation · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation-induced liver damage (RILD) has become a limitation in radiotherapy for hepatocellular carcinoma. We established a rabbit model of RILD by CyberKnife. Electron microscopy analysis revealed obvious nuclear atrophy and disposition of fat in the nucleus after irradiation. We then utilized a mass spectrometry-based label-free relative quantitative proteomics approach to compare global proteomic changes of rabbit liver in response to radiation. In total, 2365 proteins were identified, including 338 proteins that were significantly dysregulated between irradiated and nonirradiated liver tissues. These differentially expressed proteins included USP47, POLR2A, CSTB, MCFD2, and CSNK2A1. Real-time polymerase chain reaction confirmed that

Indexed as

animal modellabel-free quantitative proteomicsradiationradiation-induced liver damage

Identifiers

PMID31827415
PMCPMC6886284
OpenAlexW2991064036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.