ArticleNature2020
HBO1 is required for the maintenance of leukaemia stem cells.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
115 citing papers in PubMed, 172 citations in OpenAlex.
- Research progress on lysine acetylation (Review).International journal of molecular medicine · 2026Review
- Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses.The Journal of biological chemistry · 2026Article
- Article
- HBO1 suppresses anti-tumor immunity of CD8⁺ T Cells in thyroid cancer by recruiting BRD4 to regulate VTCN1 expression.Cancer immunology, immunotherapy : CII · 2026Article
- Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes.bioRxiv : the preprint server for biology · 2026Article
- Distinct roles of the JADE and BRPF scaffolding subunits of the acetyltransferase HBO1 complex.Nature communications · 2026Article
- Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML.Blood · 2026Article
- The Mutational Landscape of Acute Myeloid Leukemia and Its Impact.International journal of molecular sciences · 2026Review
- Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.Neuron · 2026Article
- Hierarchical small molecule inhibition of MYST acetyltransferases.Nature communications · 2026Article
- Histone acetyltransferase HBO1 in cancer biology: Essential mechanisms and implications for targeted therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2026Review
- SLC25A1 reprograms mitochondrial and fatty acid metabolism to promote the progression of acute myeloid leukemia.Haematologica · 2026Article
- CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples.Molecular cell · 2026Article
- Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.bioRxiv : the preprint server for biology · 2026Article
- Pathophysiological significance of impaired KAT7-dependent histone H3K14 acetylation during zinc deficiency.Nature communications · 2026Article
- Biological Activity and Structural Biology of Current KAT6A Inhibitor Chemotypes.Journal of medicinal chemistry · 2026Article
- Regulating Ferroptosis in Leukemic Stem Cells: From Stemness Preservation to Targeted Differentiation Strategies.Stem cell reviews and reports · 2026Review
- Aging-dependent reduction of KAT7/HBO1 activity impairs imMKCL-based platelet production by promoting immune properties.Stem cell reports · 2025Article
- Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes.Cancer discovery · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 12 institutions in 5 countries.
Laura MacPhersonPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Juliana AnokyePeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Miriam M YeungPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Enid Y N LamPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Yih-Chih ChanPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Chen-Fang WengPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Paul YehPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Kathy KnezevicPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Miriam S ButlerPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Annabelle HoeglDepartment of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kah-Lok ChanPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Marian L BurrPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Linden J GearingThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Tracy WillsonThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Joy LiuThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Jarny ChoiThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Yuqing YangThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Rebecca A BilardiThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Hendrik FalkThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Nghi NguyenMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Paul A StuppleCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Thomas S PeatCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Ming ZhangThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Melanie de SilvaThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Catalina Carrasco-PozoCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Vicky M AveryCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Poh Sim KhooCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Olan DolezalCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Matthew L DennisCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Stewart NuttallCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Regina SurjadiCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Janet NewmanCancer Therapeutics CRC, Melbourne, Victoria, Australia.
Bin RenCancer Therapeutics CRC, Melbourne, Victoria, Australia.
David J LeaverMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Yuxin SunMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Jonathan B BaellMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Oliver DoveyWellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, UK.
George S VassiliouWellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, UK.
Florian GrebienInstitute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria.
Sarah-Jane DawsonPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Ian P StreetThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Brendon J MonahanThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Christopher J BurnsThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Chunaram ChoudharyDepartment of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Marnie E BlewittThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Anne K VossThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Tim ThomasThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Mark A DawsonPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Mark.Dawson@petermac.org.
Walter and Eliza Hall Institute of Medical Research · AUPeter MacCallum Cancer Centre · AUCommonwealth Scientific and Industrial Research Organisation · AUUniversity of Melbourne · AUMonash University · AUGriffith University · AUUniversity of Copenhagen · DKChildren's Cancer Institute Australia · AUNanjing Tech University · CNUniversity of Cambridge · GBUniversity of Veterinary Medicine Vienna · ATWellcome Sanger Institute · GB
Funding
Cancer Research UK 20097Cancer Research UK 23015Howard Hughes Medical InstituteMedical Research Council MC_PC_12009
Abstract
Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)
Indexed as
AnimalsCell Line, TumorHistone AcetyltransferasesHumansLeukemia, Myeloid, AcuteMiceMice, Inbred C57BLModels, MolecularNeoplastic Stem CellsProtein Structure, TertiaryHistone AcetyltransferasesKAT7 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.