ArticleNature2020
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 2 pooled it
13.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
194 citing papers in PubMed, 2 syntheses or guidelines pooled it, 323 citations in OpenAlex.
- Effectiveness and Safety of JAK Inhibitors in Autoinflammatory Diseases: A Systematic Review.Frontiers in medicine · 2022Pooled it
- Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.Nature reviews. Drug discovery · 2020Pooled it
- A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease-Like Autoinflammatory Syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death.Nature structural & molecular biology · 2026Article
- Review
- cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A.Cell death and differentiation · 2026Article
- The dual role of RIPK family in IBD: from cell death to therapeutic targeting.Molecular medicine (Cambridge, Mass.) · 2026Review
- Caspase-8 silences cell death-independent constitutive immune activation driven by tonic TNF-α.EMBO reports · 2026Article
- Monogenic autoimmune and autoinflammatory disorders in adulthood: recent discoveries and implications for rheumatology practice.Rheumatology (Oxford, England) · 2026Review
- Z-nucleic acid-mediated PANoptosis in infection, inflammation, and cancer.Communications biology · 2026Review
- A century of cell death research.Journal of cell science · 2026Review
- c-FLIP as a master regulator of immune homeostasis and disease mechanisms.Cell death & disease · 2026Review
- RIPK1 ubiquitination regulates its kinase-independent function in development and inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- ADA2-deficient cells exhibit increased levels of cell death and metabolic disturbances.Cell death discovery · 2026Article
- CD8Nature communications · 2026Article
- Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy.Nature communications · 2026Article
- RIPK1 regulates β-cell fate via actions on gene expression and kinase signaling in a mouse model of β-cell self-reactivity.Cell death & disease · 2026Article
- Receptor-Interacting Protein Kinase 1 (RIPK1): A Potential Therapeutic Target in Ischemic Stroke.Molecular neurobiology · 2026Review
- Heat stroke and the liver: mechanisms of injury and therapeutic strategies.European journal of medical research · 2026Review
134 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 11 institutions in 3 countries.
Najoua Lalaoui *The Walter and Eliza Hall Institute, Parkville, Victoria, Australia. lalaoui@wehi.edu.au.
Steven E Boyden *Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. steven.boyden@genetics.utah.edu.
Hirotsugu Oda *Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Geryl M WoodInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Deborah L StoneInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Diep ChauThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Lin LiuThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Monique StoffelsInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Tobias KratinaThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Kate E LawlorCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Kristien J M ZaalLight Imaging Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Patrycja M HoffmannInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Nima EtemadiThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Kristy Shield-ArtinThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Christine BibenThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Wanxia Li TsaiTranslational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Mary D BlakeTranslational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Hye Sun KuehnDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Dan YangTranslational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Holly AndertonThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Natasha SilkeThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Laurens WachsmuthInstitute for Genetics & Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Lixin ZhengMolecular Development of the Immune System Section, Laboratory of Immune System Biology; Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Natalia Sampaio MouraInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
David B BeckInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Gustavo Gutierrez-CruzLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Amanda K OmbrelloInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Gineth P Pinto-PatarroyoInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Andrew J KuehThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Marco J HeroldThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Cathrine HallThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Hongying WangInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jae Jin ChaeInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Natalia I DmitrievaTranslational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Mark McKenzieThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Amanda LightThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Beverly K BarhamInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Anne JonesInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Tina M RomeoInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Qing ZhouInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Ivona AksentijevichInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
James C MullikinNIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Andrew J GrossDivision of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Anthony K ShumDivision of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Edwin D HawkinsThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Seth L MastersThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Michael J LenardoMolecular Development of the Immune System Section, Laboratory of Immune System Biology; Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Manfred BoehmTranslational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Sergio D RosenzweigDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Manolis PasparakisInstitute for Genetics & Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Anne K VossThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia.
Massimo GadinaTranslational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Daniel L KastnerInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. kastnerd@mail.nih.gov.
John SilkeThe Walter and Eliza Hall Institute, Parkville, Victoria, Australia. silke@wehi.edu.au.
National Institutes of Health · USWalter and Eliza Hall Institute of Medical Research · AUNational Human Genome Research Institute · USUniversity of Melbourne · AUNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DENational Heart Lung and Blood Institute · USNational Institutes of Health Clinical Center · USUniversity of California, San Francisco · USHudson Institute of Medical Research · AUNational Institute of Allergy and Infectious Diseases · US
Funding
Inter- and Intra-Species Comparative SequencingZIBHG000196 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI THOMAS, JAMES · 2009 to 2025
$177.6MTranslational Immunology research: a support for clinical immunological researchZICAR041181 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GADINA, MASSIMO · 2009 to 2025
$31.5MGenetics, Pathophysiology, and Treatment of Recessive Autoinflammatory DiseasesZIAHG200372 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2025
$27.2MStudies of Inherited Causes of Fungal SusceptabilityZIAAI001122 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENZWEIG, SERGIO · 2010 to 2025
$26.0MGenetics, Pathophysiology, and Treatment of Dominant Autoinflammatory DiseasesZIAHG200373 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KASTNER, DANIEL · 2011 to 2024
$21.0MMolecular Mechanisms and Treatment Of Autoimmunity In Man And Animal ModelsZIAAI000717 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2009 to 2025
$13.2MHigh Throughput Next Generation Sequencing: supports genomics and epigenomics research in muscle, skin, bone and autoimmune diseases.ZICAR041207 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI DELL'ORSO, STEFANIA · 2016 to 2025
$12.3MDefining the Role of Thymic Tolerance in the Pathogenesis of the COPA syndromeR01AI137249 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHUM, ANTHONY · 2018 to 2022
$2.4MTranslational studies of autoimmune-mediated lung diseaseR01HL122533 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHUM, ANTHONY · 2015 to 2019
$1.9MMutation Analysis Of Selected Lymphoid Immune DisordersZIACL010304 · CLC · CLINICAL CENTER · PI ROSENZWEIG, SERGIO · 2009 to 2025
$0kEuropean Research Council 787826NHLBI NIH HHS R01 HL122533NIAID NIH HHS R01 AI137249
Abstract
RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage
Indexed as
MutationAnimalsCaspase 3Caspase 8FemaleHereditary Autoinflammatory DiseasesHumansMaleMAP Kinase Kinase KinasesMiceMice, Inbred C57BLMice, KnockoutPedigreeReceptor-Interacting Protein Serine-Threonine KinasesCasp3 protein, mouseCasp8 protein, mouseCaspase 3Caspase 8Map3k9 protein, mouseMAP Kinase Kinase KinasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanRipk1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.