ArticleEuropean journal of clinical nutrition2020
Low serum 25-hydroxyvitamin D levels may increase the detrimental effect of VDR variants on the risk of essential hypertension.
Article in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.
- Effect of vitamin BBMJ open · 2024Pooled it
- Serum Vitamin D Levels in Relation to Hypertension and Pre-hypertension in Adults: A Systematic Review and Dose-Response Meta-Analysis of Epidemiologic Studies.Frontiers in nutrition · 2022Pooled it
- The Relationship of Certain Diseases and Dietary Inflammatory Index in Older Adults: A Narrative Review.Current nutrition reports · 2024Review
- Efficacy of Vitamin-D supplementation in improving the prognosis of H-type hypertension in elderly patients.Pakistan journal of medical sciences · 2024Article
- Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential Hypertension.International journal of clinical practice · 2022Article
- Vitamin D Receptor Is a Sepsis-Susceptibility Gene in Chinese Children.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The influence of VDR polymorphisms on the type 2 diabetes susceptibility in Chinese: an interaction with hypertriglyceridemia.Molecular genetics and genomics : MGG · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesThe present cross-sectional study evaluated the association of vitamin D receptor (VDR) variants with serum 25(OH)D SUBJECTS/
methods1539 patients were eligible in the study population. Two loci in VDR gene (rs2239179, rs2189480) were genotyped by TaqMan probe assays. Logistic regression, Kruskal-Wallis rank test and Chi-square test were used to determine the association among VDR polymorphisms, serum vitamin D metabolites, and the risk of EH. Interaction plots were performed to explain the interaction effects of circulating 25(OH)D
resultsAfter potential confounding adjustment, we observed that the mutations of VDR (rs2239179/rs2189480) were associated with the increased risk of EH (P < 0.05). Moreover, plasma 25(OH)D
conclusionsOur results suggested that the mutations of VDR may accelerate the progression of EH etiology, especially when suffering hypovitaminnosis D and insufficiency.
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