Evidence map›Paper›PMID 31827196›Full record

ArticleScientific reports2019

Antioxidant, Anticancer Activity and Phytochemical Analysis of Green Algae, Chaetomorpha Collected from the Arabian Gulf.

Samina Hyder Haq, Ghaida Al-Ruwaished, Moudhi Abdullah Al-Mutlaq, Sundus Ali Naji, Maha Al-Mogren, Sarah Al-Rashed, Qura Tul Ain, Abir Abdullah Al-Amro, Adnan Al-Mussallam

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 130 citations in OpenAlex.

  1. Article
  2. Review
  3. Evaluation of Anticancer Potential ofAntioxidants (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Potential of Corncob Extract on the Expression of Ki-67 and Caspase3 in Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. The Ocean's Pharmacy: Health Discoveries in Marine Algae.Molecules (Basel, Switzerland) · 2024
    Review
  16. Fermentation of micro- and macroalgae as a way to produce value-added products.Biotechnology reports (Amsterdam, Netherlands) · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Samina Hyder HaqBiochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. shaq@ksu.edu.sa.ORCID http://orcid.org/0000-0002-8617-3767
Ghaida Al-RuwaishedBiochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Moudhi Abdullah Al-MutlaqBiochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Sundus Ali NajiBiochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Maha Al-MogrenBiochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Sarah Al-RashedMicrobiology and Botany Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Qura Tul AinThe Wellman Centre for Photomedicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-3651-2337
Abir Abdullah Al-AmroBiochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Adnan Al-MussallamChemist, Cosmetic Department, Saudi Food and Drug Authority, Riyadh, Saudi Arabia.
King Saud University · SAHarvard University · USSaudi Arabian Monetary Authority · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seaweeds are a group of marine multicellular algae; the presence of antioxidant phytochemical constituents in Seaweed Chaetomorpha sp. extracts has received attention for their role in the prevention of human diseases. This study explores the phytochemical constituents, antioxidant, and anticancer properties of the Cladophoraceae, Chaetomorpha sp. Energy dispersive x-ray spectroscopy (EDX), and Gas chromatography-mass spectrometry (GC/MS) were performed to study the chemical structure and chemical formula. Different concentrations of ethanol and aqueous extracts of Chaetomorpha were used to estimate antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and total flavonoid, phenolic, and tannins content assays. Anti-tumor activity against breast cancer cell lines (MCF-7 and MDA-MB-231) was assessed by 3-(4,5-Dimethylthiazol-2-cyl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. The EDX analysis indicated the presence of oxygen, silicon, and calcium as dominant elements. Antioxidant assays indicated that the ethanol extracts of Chaetomorpha consisted of a total of 189.14 ± 0.99 mg QE/g flavonoid content, 21.92 ± 0.43 mg GAE/g phenolic content and 21.81 ± 0.04 mg GAE/g tannins content. The DPPH radical scavenging assay exhibited higher antioxidant activity IC

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsCell Line, TumorCell ProliferationChlorophytaHumansPhytochemicalsPlant ExtractsAntineoplastic Agents, PhytogenicAntioxidantsPhytochemicalsPlant Extracts

Identifiers

PMID31827196
PMCPMC6906397
OpenAlexW2995168852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.