Evidence map›Paper›PMID 31827175›Full record

ArticleScientific reports2019

West Asian sources of the Eurasian component in Ethiopians: a reassessment.

Ludovica Molinaro, Francesco Montinaro, Burak Yelmen, Davide Marnetto, Doron M Behar, Toomas Kivisild, Luca Pagani

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Rapid Bioethical Assessment forEthiopian journal of health sciences · 2023
    Article
  5. Article
  6. Comparative whole-genome sequence analysis ofFrontiers in microbiology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ludovica MolinaroEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia. lu.molinaro8@gmail.com.
Francesco MontinaroEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Burak YelmenEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Davide MarnettoEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Doron M BeharEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Toomas KivisildEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.
Luca PaganiEstonian Biocentre, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The presence of genomic signatures of Eurasian origin in contemporary Ethiopians has been reported by several authors and estimated to have arrived in the area from 3000 years ago. Several studies reported plausible source populations for such a signature, using haplotype based methods on modern data or single-site methods on modern or ancient data. These studies did not reach a consensus and suggested an Anatolian or Sardinia-like proxy, broadly Levantine or Neolithic Levantine as possible sources. We demonstrate, however, that the deeply divergent, autochthonous African component which accounts for ~50% of most contemporary Ethiopian genomes, affects the overall allele frequency spectrum to an extent that makes it hard to control for it and, at once, to discern between subtly different, yet important, Eurasian sources (such as Anatolian or Levant Neolithic ones). Here we re-assess pattern of allele sharing between the Eurasian component of Ethiopians (here called "NAF" for Non African) and ancient and modern proxies. Our results unveil a genomic legacy that may connect the Eurasian genetic component of contemporary Ethiopians with Sea People and with population movements that affected the Mediterranean area and the Levant after the fall of the Minoan civilization.

Indexed as

Genetic VariationGenome, HumanHuman MigrationAsian PeopleBlack PeopleEthiopiaGene FrequencyGenetics, PopulationGenomicsHumansPhylogeny

Identifiers

PMID31827175
PMCPMC6906521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.