ArticleScientific reports2019
Induction of specific adaptive immune responses by immunization with newly designed artificial glycosphingolipids.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Antibodies induced by antigen-containing liposomes as immunogens preferentially recognize their antigens present on lipid vesicles.Scientific reports · 2026Article
- Isolation and characterization ofFrontiers in microbiology · 2026Article
- Oleic acid enriched diet affects the metabolome composition of the hybrid grouper infected with vibriosis.Fish physiology and biochemistry · 2024Article
- Characterization of antibodies induced by immunization of mice with isoglobotrihexosylceramide (iGb3).Biochemistry and biophysics reports · 2024Article
- Serum components influence antibody reactivity to glycan and DNA antigens.Scientific reports · 2023Article
- Biology of GD2 ganglioside: implications for cancer immunotherapy.Frontiers in pharmacology · 2023Review
- Advances in Infectious Disease Vaccine Adjuvants.Vaccines · 2022Review
- Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma.International journal of molecular sciences · 2022Review
- Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling.International journal of molecular sciences · 2021Review
- The Role of Sphingolipids in Cancer Immunotherapy.International journal of molecular sciences · 2021Review
- Application of the Antibody-Inducing Activity of Glycosphingolipids to Human Diseases.International journal of molecular sciences · 2021Review
- Purification of anti-glycoconjugate monoclonal antibodies using newly developed porous zirconia particles.Scientific reports · 2021Article
- Isolation and Characterization of Antibodies Induced by Immunization with TNF-α Inducible Globotetraosylceramide.International journal of molecular sciences · 2020Article
- Dietary Control of Ganglioside Expression in Mammalian Tissues.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously found that artificial glycosphingolipids (artGSLs) containing very-long-chain fatty acids behave as strong immunogens in mice and promote the production of antibodies recognizing the oligosaccharide portion of artGSLs as the epitope. Here, we report that the oligosaccharide structure of artGSLs influences these immunogenic properties. We evaluated the antibody-inducing activity of artGSLs with different oligosaccharide structures in mice and found strong IgG-inducing activity only with an artGSL containing a core-fucosylated tetraoligosaccharide (Manβ1,4GlcNAcβ1,4[Fucα1,6]GlcNAc). To characterize the immunogenic properties of this artGSL, we analyzed various derivatives and found that the non-reducing terminal mannose structure was critical for the antibody-inducing activity. These artGSLs also exhibited IgG-inducing activity dependent on co-administration of lipid A adjuvant, but no cytokine-inducing activity similar to α-galactosylceramide was detected. Furthermore, repetitive immunization with the artGSL promoted the production of antibodies against a core-fucosylated α-fetoprotein isoform (AFP-L3) known as a hepatocellular carcinoma-specific antigen. These results indicate that the newly designed artGSLs specifically induce adaptive immune responses and promote antibody production by B cells, which can be utilized to develop anti-glycoconjugate antibodies and cancer vaccines targeting tumor-associated carbohydrate antigens.
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