ArticleNature communications2019
Giant single molecule chemistry events observed from a tetrachloroaurate(III) embedded Mycobacterium smegmatis porin A nanopore.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- An engineered nanopore identifies saccharides, amino acids, peptides and ribonucleotides.Nature biotechnology · 2026Article
- Understanding single-molecule reactions using nanopore-based techniques.Nature chemistry · 2025Review
- Native globular ferritin nanopore sensor.Nature communications · 2025Article
- Nanopore Environmental Analysis.JACS Au · 2025Review
- Single-Molecule Electrical Profiling of Peptides and Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Probe-assisted detection of FeBiosensors & bioelectronics · 2024Article
- Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore.Nature methods · 2024Article
- Nanopore analysis of cis-diols in fruits.Nature communications · 2024Article
- Nanopore analysis of salvianolic acids in herbal medicines.Nature communications · 2024Article
- Unambiguous discrimination of all 20 proteinogenic amino acids and their modifications by nanopore.Nature methods · 2024Article
- Real-time label-free detection of dynamic aptamer-small molecule interactions using a nanopore nucleic acid conformational sensor.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing.Clinical epigenetics · 2022Review
- Expanding the Molecular Alphabet of DNA-Based Data Storage Systems with Neural Network Nanopore Readout Processing.Nano letters · 2022Article
- Preparation ofBiophysics reports · 2021Article
- Programmable nano-reactors for stochastic sensing.Nature communications · 2021Article
- Nanopore sensing: A physical-chemical approach.Biochimica et biophysica acta. Biomembranes · 2021Review
- Recent advances in biological nanopores for nanopore sequencing, sensing and comparison of functional variations in MspA mutants.RSC advances · 2021Review
- Rapid and multiplex preparation of engineeredChemical science · 2021Article
- Towards explicit regulating-ion-transport: nanochannels with only function-elements at outer-surface.Nature communications · 2021Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological nanopores are capable of resolving small analytes down to a monoatomic ion. In this research, tetrachloroaurate(III), a polyatomic ion, is discovered to bind to the methionine residue (M113) of a wild-type α-hemolysin by reversible Au(III)-thioether coordination. However, the cylindrical pore geometry of α-hemolysin generates shallow ionic binding events (~5-6 pA) and may have introduced other undesired interactions. Inspired by nanopore sequencing, a Mycobacterium smegmatis porin A (MspA) nanopore, which possesses a conical pore geometry, is mutated to bind tetrachloroaurate(III). Subsequently, further amplified blockage events (up to ~55 pA) are observed, which report the largest single ion binding event from a nanopore measurement. By taking the embedded Au(III) as an atomic bridge, the MspA nanopore is enabled to discriminate between different biothiols from single molecule readouts. These phenomena suggest that MspA is advantageous for single molecule chemistry investigations and has applications as a hybrid biological nanopore with atomic adaptors.
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