Evidence map›Paper›PMID 31827017›Full record

ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2019

"Dynamic" molecular recognition and chirality segregation utilizing concepts of molecular machines and molecular assemblies.

Seiji Shinkai

Abstract readReview
In one paragraph

Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Seiji ShinkaiInstitute of Advanced Study, Kyushu University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need to measure the concentration of selected ions and small organic molecules in both in vivo and in vitro processes is continuously increasing beyond the borders of various research fields. This need has been fulfilled using "host-guest chemistry", or in general, by the use of "molecular recognition". The basic idea in these research fields was derived from the 1 : 1 host-guest interaction based on the "key-and-lock" concept. However, we have experienced that only with this classical concept, more precise, higher-order recognition faces serious difficulty. In this review article, I wish to explain that the introduction of two new concepts, i.e., the dynamic action of molecular systems and the amplification effect of molecular assemblies, overcame the limitation of the "key-and-lock" concept. In fact, we have found that even "complete" chirality segregation can be achieved under optimal conditions.

Indexed as

Allosteric SiteKineticsModels, MolecularMolecular ConformationOrganic ChemicalsPhotochemical ProcessesStereoisomerismThermodynamicsOrganic Chemicalsaggregation-based chirality segregationaggregation-induced emissionhomotropic allosterismmolecular machinesmolecular recognitionmolecular triggers and switches

Identifiers

PMID31827017
PMCPMC6920079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.