Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization.
Pedro Alves-Peixoto, Maria Férez, Cory J Knudson, Carolina R Melo-Silva, Colby Stotesbury, Eric B Wong, Margarida Correia-Neves, Luis J Sigal
Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 2 institutions in 2 countries.
Pedro Alves-PeixotoDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-6082-6838
Maria FérezDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Cory J KnudsonDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Carolina R Melo-SilvaDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Colby StotesburyDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Eric B WongDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Margarida Correia-NevesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Luis J SigalDepartment of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA Luis.Sigal@jefferson.edu.ORCID 0000-0001-6642-5472
Thomas Jefferson University · USUniversity of Minho · PT
Funding
X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
Orthropoxvirus Pathogenesis and VaccinesR01AI065544 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SIGAL, LUIS J · 2006 to 2016
$5.7M
Inflammatory monocytes in the draining lymph node of ECTV infected miceR01AI110457 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SIGAL, LUIS J · 2015 to 2019
$2.3M
Natural Killer Cell Deficiencies in Aging MiceR01AG048602 · NIA · THOMAS JEFFERSON UNIVERSITY · PI SIGAL, LUIS J · 2014 to 2018
$1.8M
Training grant on Vaccines and Immunotherapies for Infectious Diseases and CancerT32AI134646 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SCHNELL, MATTHIAS JOHANNES, SIGAL, LUIS J · 2018 to 2022
$1.1M
The Immune Response to Ectromelia Virus in the Draining Lymph NodeR56AI110457 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SIGAL, LUIS J · 2014 to 2021
It is well established that chronic viral infections can cause immune suppression, resulting in increased susceptibility to other infectious diseases. However, the effects of chronic viral infection on T-cell responses and vaccination against highly pathogenic viruses are not well understood. We have recently shown that C57BL/6 (B6) mice lose their natural resistance to wild-type (WT) ectromelia virus (ECTV) when chronically infected with lymphocytic choriomeningitis virus (LCMV) clone 13 (CL13). Here we compared the T-cell response to ECTV in previously immunologically naive mice that were chronically infected with CL13 or that were convalescent from acute infection with the Armstrong (Arm) strain of LCMV. Our results show that mice that were chronically infected with CL13 but not those that had recovered from Arm infection have highly defective ECTV-specific CD8
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization. · full record | OpenQuestion