Evidence map›Paper›PMID 31826988›Full record

ArticleJournal of virology2020

RNA Polymerase II Promoter-Proximal Pausing and Release to Elongation Are Key Steps Regulating Herpes Simplex Virus 1 Transcription.

Claire H Birkenheuer, Joel D Baines

Abstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Claire H BirkenheuerDepartment of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA.
Joel D BainesDepartment of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA jbaines@lsu.edu.ORCID 0000-0002-6397-2830

Funding

Protein CoreP30GM110760 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI BAINES, JOEL D. · 2014 to 2018
$5.6M
Nucleocapsid Envelopment Herpes Simplex Virus-1R01AI052341 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI BAINES, JOEL D. · 2003 to 2013
$3.6M
How HSV repurposes host transcriptional machinery for viral gene expressionR01AI141968 · NIAID · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI BAINES, JOEL D. · 2019 to 2023
$1.9M
NIAID NIH HHS R01 AI052341NIAID NIH HHS R01 AI141968NIGMS NIH HHS P30 GM110760
6 · The paper itself

Abstract

Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (Pol II). Expression of viral immediate early (α) genes is followed sequentially by early (β), late (γ

Indexed as

AnimalsCell LineCyclin-Dependent Kinase 9DNA ReplicationDNA, ViralGenes, ViralGenome, ViralHerpesvirus 1, HumanHumansPromoter Regions, GeneticRNA, MessengerRNA Polymerase IITranscription, GeneticTranscription Initiation SiteVirus ReplicationCDK9 protein, humanCyclin-Dependent Kinase 9DNA, ViralRNA, MessengerRNA Polymerase IIherpes simplex virusherpesvirusesRNA polymerasestranscriptiontranscriptional regulation

Identifiers

PMID31826988
PMCPMC7022368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.