Evidence map›Paper›PMID 31826968›Full record

ArticlemSphere2019

The Modified Surface Killing Assay Distinguishes between Protective and Nonprotective Antibodies to PspA.

Kristopher R Genschmer, Cintia F M Vadesilho, Larry S McDaniel, Sang-Sang Park, Yvette Hale, Eliane N Miyaji, David E Briles

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. AliC and AliD of nonencapsulatedFrontiers in cellular and infection microbiology · 2025
    Article
  2. Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kristopher R GenschmerDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-1836-9522
Cintia F M VadesilhoLaboratório de Bacteriologia, Instituto Butantan, Sao Paulo, Sao Paulo, Brazil.
Larry S McDanielDepartment of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0002-1649-7563
Sang-Sang ParkDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Yvette HaleDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Eliane N MiyajiLaboratório de Bacteriologia, Instituto Butantan, Sao Paulo, Sao Paulo, Brazil.
David E BrilesDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA dbriles@uab.edu.
University of Alabama at Birmingham · USInstituto Butantan · BRUniversity of Mississippi Medical Center · US

Funding

PspA: A Potential Pneumococcal Vaccine ComponentR01AI021548 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRILES, DAVID E · 1985 to 2012
$6.0M
Effect of the Middle Ear Inflammation On the Inner EarR01DC006452 · NIDCD · UNIVERSITY OF MINNESOTA · PI BRILES, DAVID E, FERRIERI, PATRICIA · 2006 to 2014
$2.4M
Vaccine potential of the proline-rich domain of pneumococcal surface protein AR01AI118805 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRILES, DAVID E · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI021548NIAID NIH HHS R01 AI118805NIDCD NIH HHS R01 DC006452
6 · The paper itself

Abstract

Pneumococcal surface protein A (PspA) elicits antibody protective against lethal challenge by

Indexed as

Blood Bactericidal ActivityAnimalsAntibodies, BacterialAntibodies, MonoclonalBacterial ProteinsBinding SitesDisease Models, AnimalImmunization, PassiveImmunoassayMiceNeutrophilsPneumococcal InfectionsProtein BindingStreptococcus pneumoniaeTreatment OutcomeAntibodies, BacterialAntibodies, MonoclonalBacterial Proteinspneumococcal surface protein Amodified surface killing assaypneumococcal surface protein APspA

Identifiers

PMID31826968
PMCPMC6908419
OpenAlexW2996003691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.