ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Progression from Feature-Specific Brain Activity to Hippocampal Binding during Episodic Encoding.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Working Memory Impairment Induced by Chemotherapy-A Narrative Review.Brain sciences · 2026Review
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- How the New Interacts With the Old? Hippocampal Processing During Memory Encoding of Creative Associations With Remote or Close Inherent Semantic Relatedness.Human brain mapping · 2025Article
- The order of multisensory associative sequences is reinstated as context feature during successful recognition.Scientific reports · 2025Article
- Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pattern Separation and Pattern Completion Within the Hippocampal Circuit During Naturalistic Stimuli.Human brain mapping · 2025Article
- Differential Mnemonic Contributions of Cortical Representations during Encoding and Retrieval.Journal of cognitive neuroscience · 2024Article
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Behavioral Disorders of Spatial Cognition in Patients with Mild Cognitive Impairment due to Alzheimer's Disease: Preliminary Findings from the BDSC-MCI Project.Journal of clinical medicine · 2024Article
- Hippocampal neurons code individual episodic memories in humans.Nature human behaviour · 2023Article
- Hippocampal integration and separation processes with different temporal and spatial dynamics during learning for associative memory.Human brain mapping · 2023Article
- Article
- Cognitive neuroscience perspective on memory: overview and summary.Frontiers in human neuroscience · 2023Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Hippocampal representations switch from errors to predictions during acquisition of predictive associations.Nature communications · 2022Article
- The limited reach of surprise: Evidence against effects of surprise on memory for preceding elements of an event.Psychonomic bulletin & review · 2022Article
- Article
- Prediction errors disrupt hippocampal representations and update episodic memories.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Greater Neural Differentiation in the Ventral Visual Cortex Is Associated with Youthful Memory in Superaging.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Mapping the organization and dynamics of the posterior medial network during movie watching.NeuroImage · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The hallmark of episodic memory is recollecting multiple perceptual details tied to a specific spatial-temporal context. To remember an event, it is therefore necessary to integrate such details into a coherent representation during initial encoding. Here we tested how the brain encodes and binds multiple, distinct kinds of features in parallel, and how this process evolves over time during the event itself. We analyzed data from 27 human subjects (16 females, 11 males) who learned a series of objects uniquely associated with a color, a panoramic scene location, and an emotional sound while fMRI data were collected. By modeling how brain activity relates to memory for upcoming or just-viewed information, we were able to test how the neural signatures of individual features as well as the integrated event changed over the course of encoding. We observed a striking dissociation between early and late encoding processes: left inferior frontal and visuo-perceptual signals at the onset of an event tracked the amount of detail subsequently recalled and were dissociable based on distinct remembered features. In contrast, memory-related brain activity shifted to the left hippocampus toward the end of an event, which was particularly sensitive to binding item color and sound associations with spatial information. These results provide evidence of early, simultaneous feature-specific neural responses during episodic encoding that predict later remembering and suggest that the hippocampus integrates these features into a coherent experience at an event transition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.