ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Temporal Neurogenesis Patterning of Spinal p3-V3 Interneurons into Divergent Subpopulation Assemblies.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Gene expression programs underlying spinal commissural neuron differentiation and axon growth across the midline.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.Neural regeneration research · 2026Article
- Transcriptional profiling of extraocular motor neurons revealsbioRxiv : the preprint server for biology · 2026Article
- Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors.Science advances · 2026Article
- Ascending propriospinal modulation of thoracic sympathetic preganglionic neurons during lumbar locomotor activity.Frontiers in neural circuits · 2026Article
- Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity.eLife · 2024Article
- Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.Cell reports · 2024Article
- The organization of spinal neurons: Insights from single cell sequencing.Current opinion in neurobiology · 2023Review
- Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction.Current opinion in neurobiology · 2023Review
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
- Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain.Genes & development · 2023Article
- Organization of the gravity-sensing system in zebrafish.Nature communications · 2022Article
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.eLife · 2022Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Transcriptional and epigenetic regulation of temporal patterning in neural progenitors.Developmental biology · 2022Review
- A shared transcriptional code orchestrates temporal patterning of the central nervous system.PLoS biology · 2021Article
- The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord.International journal of molecular sciences · 2021Review
- Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia.eLife · 2021Article
- Could Gait Biomechanics Become a Marker of Atypical Neuronal Circuitry in Human Development?-The Example of Autism Spectrum Disorder.Frontiers in bioengineering and biotechnology · 2021Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal diversity provides the spinal cord with the functional flexibility required to perform complex motor tasks. Spinal neurons arise during early embryonic development with the establishment of spatially and molecularly discrete progenitor domains that give rise to distinct, but highly heterogeneous, postmitotic interneuron (IN) populations. Our previous studies have shown that Sim1-expressing V3 INs, originating from the p3 progenitor domain, are anatomically and physiologically divergent. However, the developmental logic guiding V3 subpopulation diversity remains elusive. In specific cases of other IN classes, neurogenesis timing can play a role in determining the ultimate fates and unique characteristics of distinctive subpopulations. To examine whether neurogenesis timing contributes to V3 diversity, we systematically investigated the temporal neurogenesis profiles of V3 INs in the mouse spinal cord. Our work uncovered that V3 INs were organized into either early-born [embryonic day 9.5 (E9.5) to E10.5] or late-born (E11.5-E12.5) neurogenic waves. Early-born V3 INs displayed both ascending and descending commissural projections and clustered into subgroups across dorsoventral spinal laminae. In contrast, late-born V3 INs became fate-restricted to ventral laminae and displayed mostly descending and local commissural projections and uniform membrane properties. Furthermore, we found that the postmitotic transcription factor, Sim1, although expressed in all V3 INs, exclusively regulated the dorsal clustering and electrophysiological diversification of early-born, but not late-born, V3 INs, which indicates that neurogenesis timing may enable newborn V3 INs to interact with different postmitotic differentiation pathways. Thus, our work demonstrates neurogenesis timing as a developmental mechanism underlying the postmitotic differentiation of V3 INs into distinct subpopulation assemblies.
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