Evidence map›Paper›PMID 31826916›Full record

ArticleeNeuro

Multiscale Imaging Reveals Aberrant Functional Connectome Organization and Elevated Dorsal Striatal

Luis M Colon-Perez, Sean M Turner, Katelyn N Lubke, Marjory Pompilus, Marcelo Febo, Sara N Burke

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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  9. 'Arc'-hitecture of normal cognitive aging.Ageing research reviews · 2022
    Review
  10. A Neuroscience Primer for Integrating Geroscience With the Neurobiology of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luis M Colon-PerezDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.
Sean M TurnerDepartment of Neuroscience, University of Florida, Gainesville, Florida 32610.
Katelyn N LubkeDepartment of Neuroscience, University of Florida, Gainesville, Florida 32610.
Marjory PompilusDepartment of Neuroscience, University of Florida, Gainesville, Florida 32610.
Marcelo FeboDepartment of Neuroscience, University of Florida, Gainesville, Florida 32610 burkes@ufl.edu febo@ufl.edu.
Sara N BurkeDepartment of Neuroscience, University of Florida, Gainesville, Florida 32610 burkes@ufl.edu febo@ufl.edu.ORCID 0000-0002-1773-1294
University of Florida · USUniversity of California, Irvine · US

Funding

University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2015 to 2019
$7.3M
The contribution of declines in functional connectivity to cognitive agingR01AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2016 to 2025
$3.2M
The contribution of declines in functional connectivity to cognitive agingRF1AG049722 · NIA · UNIVERSITY OF FLORIDA · PI BURKE, SARA N · 2021 to 2021
$2.0M
NIA NIH HHS P50 AG047266NIA NIH HHS R01 AG049722NIA NIH HHS RF1 AG049722
6 · The paper itself

Abstract

The functional connectome reflects a network architecture enabling adaptive behavior that becomes vulnerable in advanced age. The cellular mechanisms that contribute to altered functional connectivity in old age, however, are not known. Here we used a multiscale imaging approach to link age-related changes in the functional connectome to altered expression of the activity-dependent immediate-early gene

Indexed as

ConnectomePractice, PsychologicalAgingAnimalsAssociation LearningBehavior, AnimalCytoskeletal ProteinsGyrus CinguliMagnetic Resonance ImagingMemory, Short-TermNeostriatumNerve Tissue ProteinsRatsactivity regulated cytoskeletal-associated proteinCytoskeletal ProteinsNerve Tissue Proteinsanterior cingulate cortexfunctional connectivitygraph theoryprefrontal cortexworking memory

Identifiers

PMID31826916
PMCPMC6978920
OpenAlexW2995637990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.