ArticleStroke2020
Neuroimaging in Ischemic Stroke Is Different Between Men and Women in the DEFUSE 3 Cohort.
Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Association between tirofiban administration and sex in outcomes following endovascular treatment for large vessel occlusion stroke.Frontiers in neurology · 2026Trial
- Sex differences in imaging and clinical characteristics of patients from the WAKE-UP trial.European journal of neurology · 2023Trial
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Women.Stroke (Hoboken, N.J.) · 2026Article
- Factors Associated with Leptomeningeal Collaterals and Their Impact on Functional Outcomes in Anterior Circulation Acute Ischemic Stroke.Annals of Indian Academy of Neurology · 2026Article
- Genetic determinants of insufficiency of the collateral circulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sex differences in risk factors, stroke etiology, treatment characteristics, and outcomes after endovascular treatment for anterior circulation ischemic stroke.Frontiers in stroke · 2026Article
- Sex Differences in the Protective Effect of Brain Volume: Age Attenuates Protection in Females.medRxiv : the preprint server for health sciences · 2025Article
- Sex-Specific Vulnerabilities to Subclinical Vascular Brain Injury in Early Late-Life: The Framingham Heart Study.Annals of neurology · 2025Article
- Sex differences in Wake-Up Stroke patients characteristics and outcomes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy.European stroke journal · 2024Article
- Sex differences in outcomes of endovascular therapy for acute vertebrobasilar occlusion: data from ANGEL-ACT Registry.Journal of neurology · 2024Article
- Lean body mass and stroke volume, a sex issue.Frontiers in neurology · 2024Article
- Article
- Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study.European stroke journal · 2022Article
- Sex is a defining feature of neuroimaging phenotypes in major brain disorders.Human brain mapping · 2022Review
- Sex Differences in Collateral Circulation and Outcome After Mechanical Thrombectomy in Acute Ischemic Stroke.Frontiers in neurology · 2022Article
- MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy.Topics in magnetic resonance imaging : TMRI · 2021Review
- Effect of Sex on Clinical Outcome and Imaging after Endovascular Treatment of Large-Vessel Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- Infarct Growth despite Endovascular Thrombectomy Recanalization in Large Vessel Occlusive Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
6 authors.
Funding
Abstract
Background and Purpose- Clinical deficits from ischemic stroke are more severe in women, but the pathophysiological basis of this sex difference is unknown. Sex differences in core and penumbral volumes and their relation to outcome were assessed in this substudy of the DEFUSE 3 clinical trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke). Methods- DEFUSE 3 randomized patients to thrombectomy or medical management who presented 6 to 16 hours from last known well with proximal middle cerebral artery or internal carotid artery occlusion and had target core and perfusion mismatch volumes on computed tomography or magnetic resonance imaging. Using univariate and adjusted regression models, the effect of sex was assessed on prerandomization measures of core, perfusion, and mismatch volumes and hypoperfusion intensity ratio, and on core volume growth using 24-hour scans. Results- All patients were included in the analysis (n=182) with 90 men and 92 women. There was no sex difference in the site of baseline arterial occlusion. Adjusted by age, baseline National Institutes of Health Stroke Scale, baseline modified Rankin Scale score, time to randomization, and imaging modality, women had smaller core, hypoperfusion, and penumbral volumes than men. Median (interquartile range) volumes for core were 8.0 mL (1.9-18.4) in women versus 12.6 mL (2.7-29.6) in men, for T
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.