ArticleJournal of the American Heart Association2019
Aortic Stiffness and Age With Cognitive Performance Decline in the ELSA-Brasil Cohort.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Arterial stiffness measured by pulse wave velocity correlated with cognitive decline in hypertensive individuals: a systematic review.BMC neurology · 2024Pooled it
- Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- Genetic evidence links hypertension to accelerated brain aging.Biogerontology · 2026Article
- Carotid-femoral pulse wave velocity score, an estimator of cognitive performance in the elderly: results from the Toledo Study for Healthy Aging.GeroScience · 2024Article
- Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease.Aging and disease · 2024Review
- Estimated Pulse Wave Velocity Is Associated With a Higher Risk of Dementia in the Health and Retirement Study.American journal of hypertension · 2024Article
- Aortic Characteristic Impedance and Suspected Mild Cognitive Impairment in a Community-Based Healthy Population.Journal of the American Heart Association · 2024Article
- Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences.Physiology (Bethesda, Md.) · 2022Review
- A SAGE score cutoff that predicts high-pulse wave velocity as measured by oscillometric devices in Brazilian hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Aortic Stiffness and Age With Cognitive Performance Decline in the ELSA-Brasil Cohort.Journal of the American Heart Association · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Increased aortic stiffness has been associated with cognitive decline and dementia, but the results are inconsistent. This study investigated the longitudinal association of aortic stiffness and age with decreased cognitive performance in 3 cognitive tests. Methods and Results This study included 6927 participants, with a mean age of 58.8 years at baseline (2008-2010), who participated in the second wave (2012-2014) of the ELSA-Brasil (Brazilian Longitudinal Study of Adult Health) (interval between visits ranging from 2-6 years). Cognitive performance was evaluated by Memory, Phonemic, and Semantic Verbal Fluency and Trail B Tests, applied at both cohort visits. Associations with the carotid-femoral pulse wave velocity and age at baseline were investigated using linear models with mixed effects after adjusting for confounders. After all the adjustments, including for systolic blood pressure, the interaction term carotid-femoral pulse wave velocity×time proved to be statistically significant for Memory and Verbal Fluency Tests, indicating that the higher carotid-femoral pulse wave velocity at baseline was associated with a faster decline in cognitive performance in these tests between waves. The interaction term age×time was statistically significant for all cognitive tests, suggesting that increasing age at baseline was also associated with a faster decline in cognitive performance between waves. Conclusions In this relatively young cohort, and after a relatively short interval, an increased aortic stiffness at baseline was associated with a sharper decline in cognitive performances in memory and verbal fluency, regardless of systolic blood pressure levels. This study also showed that the decline in cognitive performance was faster among older individuals than among younger ones at baseline.
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