Evidence map›Paper›PMID 31826721›Full record

ArticleEmerging microbes & infections2019

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities.

Aline da Rocha Matos, Katharina Wunderlich, Sebastian Schloer, Klaus Schughart, Robert Geffers, Martine Seders, Marlous de Witt, Anmari Christersson, Rainer Wiewrodt, Karsten Wiebe and 11 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. In Vitro and Embryonic Evaluation of RecombinantPathogens (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Interferon-Based Therapeutics in Cancer Therapy: Past, Present, and Future.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Review
  6. Microorganisms · 2025
    Article
  7. Article
  8. An atlas of protein phosphorylation dynamics during interferon signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. 3DEmerging microbes & infections · 2022
    Article
  18. Interferon resistance of emerging SARS-CoV-2 variants.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Aline da Rocha MatosInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.
Katharina WunderlichInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.
Sebastian SchloerInstitute of Medical Biochemistry, Westfaelische Wilhelms-University, Muenster, Germany.
Klaus SchughartDepartment of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Robert GeffersGenome analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Martine SedersInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.
Marlous de WittInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.
Anmari ChristerssonInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.
Rainer WiewrodtDepartment of Medicine A, Hematology, Oncology and Respiratory Medicine, University Hospital Muenster, Muenster, Germany.
Karsten WiebeDepartment of Thoracic Surgery, University Hospital Muenster, Muenster, Germany.
Peter BarthGerhard-Domagk-Institute of Pathology, Westfaelische Wilhelms-University, Muenster, Germany.
Andreas HockeCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, Berlin, Germany.
Stefan HippenstielCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, Berlin, Germany.
Katja HönzkeCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Internal Medicine/Infectious Diseases and Respiratory Medicine, Berlin, Germany.
Ulf DittmerInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Kathrin SutterInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.
Ursula RescherInstitute of Medical Biochemistry, Westfaelische Wilhelms-University, Muenster, Germany.
Svetlana RodionychevaDepartment of Thoracic Surgery, University Hospital Muenster, Muenster, Germany.
Nicoletta MateraDepartment of Thoracic Surgery, University Hospital Muenster, Muenster, Germany.
Stephan LudwigInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.ORCID https://orcid.org/0000-0003-4490-3052
Linda BrunotteInstitute of Virology Muenster, Westfaelische Wilhelms-University, Muenster, Germany.ORCID https://orcid.org/0000-0001-8074-7400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza is an acute respiratory infection causing high morbidity and mortality in annual outbreaks worldwide. Antiviral drugs are limited and pose the risk of resistance development, calling for new treatment options. IFN-α subtypes are immune-stimulatory cytokines with strong antiviral activities against IAV

Indexed as

A549 CellsAntiviral AgentsCytokinesHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanInhibitory Concentration 50Interferon-alphaLungOrgan Culture TechniquesVirus ReplicationAntiviral AgentsCytokinesInterferon-alphaantiviralHuman lung explantIFN-α subtypeinfluenzaISG inductionMxA

Identifiers

PMID31826721
PMCPMC6913622

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.