Evidence map›Paper›PMID 31826179›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2019

Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats.

Tao Yu, Cunju Zhao, Shouzhi Hou, Weijie Zhou, Baoxin Wang, Yunzhen Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 4 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 4 syntheses or guidelines pooled it, 121 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tao YuDepartment of Spinal Surgery, Qilu Hospitial of ShanDong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0002-3163-0828
Cunju ZhaoDepartment of Spinal Surgery, Qilu Hospitial of ShanDong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0002-8680-2092
Shouzhi HouDepartment of Radiology, Liaocheng People's Hospitial, Liaocheng, Shandong, China.ORCID http://orcid.org/0000-0002-1469-8361
Weijie ZhouDepartment of Orthopedics, Liaocheng People's Hospitial, Liaocheng, Shandong, China.ORCID http://orcid.org/0000-0003-4871-0151
Baoxin WangDepartment of Orthopedics, Liaocheng People's Hospitial, Liaocheng, Shandong, China.ORCID http://orcid.org/0000-0002-2783-481X
Yunzhen ChenDepartment of Spinal Surgery, Qilu Hospitial of ShanDong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0002-5691-7200
Liaocheng People's Hospital · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes, a kind of extracellular vesicle, are promising therapeutic agents for spinal cord injury (SCI). This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b or negative control (miR NC). SCI rats were injected intravenously with exosomes (control exosomes, miRNA-29b exosomes) and BMSCs (miR NC, miRNA-29b) through the tail vein. The expression of miRNA-29b in spinal cord tissues of SCI rats was detected by qRT-PCR. The hind limb motor function was evaluated by Basso Beattie Bresnahan (BBB) score. The histopathological damage and neuronal regeneration in spinal cord tissues was observed by HE staining and immunohistochemistry, respectively. The injection of miRNA-29b exosomes and miRNA-29b BMSCs both significantly increased the expression of miRNA-29b in spinal cord tissues of SCI rats (P<0.05). Compared with SCI rats, rats in the miRNA-29b exosomes and the miRNA-29b groups exhibited improved SCI, including increased BBB score, NF200 and GAP-43 positive neurons, as well as decreased contractile nerve cell numbers and GFAP positive neurons (all P<0.05). The relieving degree of SCI was significantly higher in the miRNA-29b exosomes group than in the miRNA-29b BMSCs group (P<0.05). Exosomes secreted from miRNA-29b-modified BMSCs were effective in the repair of SCI in rats.

Indexed as

Mesenchymal Stem Cell TransplantationRecovery of FunctionTransfectionAnimalsDisease Models, AnimalExosomesFemaleImmunohistochemistryMaleMicroRNAsRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionSpinal Cord InjuriesMicroRNAs

Identifiers

PMID31826179
PMCPMC6903804
OpenAlexW2992413241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.