Evidence map›Paper›PMID 31825848›Full record

ArticleCell reports2019

Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.

Rebecca Leylek, Marcela Alcántara-Hernández, Zachary Lanzar, Anja Lüdtke, Oriana A Perez, Boris Reizis, Juliana Idoyaga

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 152 citations in OpenAlex.

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  14. Thymic Dendritic Cells Revisited.Immunological reviews · 2025
    Review
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  20. Unexpected heterogeneity and tissue-specific properties of the thymic hematopoietic antigen-presenting cell network.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rebecca LeylekMicrobiology & Immunology Department and Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Marcela Alcántara-HernándezMicrobiology & Immunology Department and Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zachary LanzarMicrobiology & Immunology Department and Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Anja LüdtkeMicrobiology & Immunology Department and Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA.
Oriana A PerezDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Boris ReizisDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Juliana IdoyagaMicrobiology & Immunology Department and Immunology Program, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: jidoyaga@stanford.edu.
Stanford University · USNew York University · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4M
Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionR37AI072571 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2018 to 2026
$5.3M
Training Program in Immunology and Inflammation.T32AI100853 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2012 to 2026
$4.5M
Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionR01AI072571 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIZIS, BORIS · 2008 to 2017
$4.1M
Harnessing human dendritic cell subsets for the design of novel immunotherapiesDP2AR069953 · NIAMS · STANFORD UNIVERSITY · PI IDOYAGA, JULIANA · 2015 to 2015
$2.4M
CyTOFS10OD016318 · OD · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2013 to 2013
$600k
Four Laser, 18 Color Cell Sorter in the SSFFS10RR025518 · NCRR · STANFORD UNIVERSITY · PI HERZENBERG, LEONARD A · 2009 to 2009
$500k
Dynamic Spatiotemporal Analysis of Immune Cells in the Tumor MicroenvironmentF32CA232666 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PEREZ, ORIANA · 2018 to 2020
$150k
NCI NIH HHS F32 CA232666NCI NIH HHS P30 CA124435NCRR NIH HHS S10 RR025518NIAID NIH HHS R01 AI072571NIAID NIH HHS R37 AI072571NIAID NIH HHS T32 AI100853NIAID NIH HHS U19 AI128949NIAMS NIH HHS DP2 AR069953NIH HHS S10 OD016318
6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDCs) are sensor cells with diverse immune functions, from type I interferon (IFN-I) production to antigen presentation, T cell activation, and tolerance. Regulation of these functions remains poorly understood but could be mediated by functionally specialized pDC subpopulations. We address pDC diversity using a high-dimensional single-cell approach: mass cytometry (CyTOF). Our analysis uncovers a murine pDC-like population that specializes in antigen presentation with limited capacity for IFN-I production. Using a multifaceted cross-species comparison, we show that this pDC-like population is the definitive murine equivalent of the recently described human AXL

Indexed as

Antigen PresentationAdultAnimalsCells, CulturedDendritic CellsFemaleFlow CytometryHumansInterferon-gammaMaleMiceMice, Inbred BALB CMice, Inbred C57BLOrthomyxoviridaeSingle-Cell AnalysisSpecies SpecificityInterferon-gammaASDCAXL(+) dendritic cellsCyTOFhumanmousenoncanonical dendritic cellsplasmacytoid dendritic cellspre-DCstransitional dendritic cellsviral infection

Identifiers

PMID31825848
PMCPMC6951814
OpenAlexW2995261558

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.