Evidence map›Paper›PMID 31825836›Full record

ArticleCell reports2019

Compromised Metabolic Reprogramming Is an Early Indicator of CD8

Shannon L Russell, Dirk A Lamprecht, Tawanda Mandizvo, Terrence T Jones, Vanessa Naidoo, Kelvin W Addicott, Chivonne Moodley, Bongani Ngcobo, David K Crossman, Gordon Wells and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. HowVaccines · 2026
    Review
  5. Review
  6. NR4A1 limits CD8Research square · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Mitochondrial Metabolism in T-Cell Exhaustion.International journal of molecular sciences · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Shannon L RussellAfrica Health Research Institute, Durban 4001, South Africa.
Dirk A LamprechtAfrica Health Research Institute, Durban 4001, South Africa.
Tawanda MandizvoAfrica Health Research Institute, Durban 4001, South Africa.
Terrence T JonesHealth Science Center (UTHSC), Department of Medicine, University of Tennessee, Memphis, TN 38163, USA.
Vanessa NaidooAfrica Health Research Institute, Durban 4001, South Africa.
Kelvin W AddicottAfrica Health Research Institute, Durban 4001, South Africa.
Chivonne MoodleyAfrica Health Research Institute, Durban 4001, South Africa.
Bongani NgcoboAfrica Health Research Institute, Durban 4001, South Africa.
David K CrossmanHeflin Center for Genomic Science, Department of Genetics, University of Alabama, Birmingham, AL 35487, USA.
Gordon WellsAfrica Health Research Institute, Durban 4001, South Africa.
Adrie J C SteynAfrica Health Research Institute, Durban 4001, South Africa; Department of Microbiology, University of Alabama, Birmingham, AL 35487, USA; Center for AIDS Research (CFAR), University of Alabama, Birmingham, AL 35487, USA; Center for Free Radical Biology (CFRB), University of Alabama, Birmingham, AL 35487, USA. Electronic address: asteyn@uab.edu.
Africa Health Research Institute · ZAUniversity of Alabama · USUniversity of Tennessee Health Science Center · US

Funding

Heme oxygenase-1 and the bioenergetic threshold of latent TB and HIV co-infectionR01AI111940 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2015 to 2019
$2.0M
METABOLIC REPROGRAMMING OF T CELL ENERGY METABOLISM IN TUBERCULOSIS AND HIVR61AI138280 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2018 to 2019
$1.0M
Immunometabolism of M. tuberculosis/HIV co-infectionR21AI127182 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEYN, ADRIE JC · 2016 to 2017
$349k
NIAID NIH HHS R01 AI111940NIAID NIH HHS R21 AI127182NIAID NIH HHS R61 AI138280
6 · The paper itself

Abstract

The immunometabolic mechanisms underlying suboptimal T cell immunity in tuberculosis remain undefined. Here, we examine how chronic Mycobacterium tuberculosis (Mtb) and M. bovis BCG infections rewire metabolic circuits and alter effector functions in lung CD8

Indexed as

GlycolysisAnimalsCD8-Positive T-LymphocytesCells, CulturedCytokinesFemaleHypoglycemic AgentsLatent TuberculosisMetforminMiceMice, Inbred C57BLMitochondriaMycobacterium bovisMycobacterium tuberculosisCytokinesHypoglycemic AgentsMetforminbioenergeticsCD8+ T cellchronic infectionexhaustionhost-directed therapyimmunometabolismmetabolic reprogramingmetforminmitochondrial dysfunctiontuberculosis

Identifiers

PMID31825836
PMCPMC6915325
OpenAlexW2996194694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.