Evidence map›Paper›PMID 31825720›Full record

ArticleMolecular biology of the cell2020

Gαq-mediated calcium dynamics and membrane tension modulate neurite plasticity.

Katherine M Pearce, Miriam Bell, Will H Linthicum, Qi Wen, Jagan Srinivasan, Padmini Rangamani, Suzanne Scarlata

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Katherine M PearceDepartment of Chemistry and Biochemistry.
Miriam BellMechanical and Aerospace Engineering Department, University of California, San Diego, La Jolla, CA 92093.
Will H LinthicumDepartment of Biomedical Engineering, and.
Qi WenDepartment of Biomedical Engineering, and.
Jagan SrinivasanDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609.
Padmini RangamaniMechanical and Aerospace Engineering Department, University of California, San Diego, La Jolla, CA 92093.
Suzanne ScarlataDepartment of Chemistry and Biochemistry.
University of California San Diego · USWorcester Polytechnic Institute · US

Funding

Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Functional connectome of sex-specific processing of social cuesR01DC016058 · NIDCD · WORCESTER POLYTECHNIC INSTITUTE · PI SRINIVASAN, JAGAN · 2017 to 2021
$1.6M
NIBIB NIH HHS T32 EB009380NIDCD NIH HHS R01 DC016058
6 · The paper itself

Abstract

The formation and disruption of synaptic connections during development are a fundamental step in neural circuit formation. Subneuronal structures such as neurites are known to be sensitive to the level of spontaneous neuronal activity, but the specifics of how neurotransmitter-induced calcium activity regulates neurite homeostasis are not yet fully understood. In response to stimulation by neurotransmitters such as acetylcholine, calcium responses in cells are mediated by the Gαq/phospholipase Cβ (PLCβ)/phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Indexed as

Neuronal PlasticityActinsAnimalsCaenorhabditis elegansCalciumGTP-Binding Protein alpha Subunits, Gq-G11Models, BiologicalNeuritesPC12 CellsPhospholipase C betaRatsReproducibility of ResultsSignal TransductionActinsCalciumGTP-Binding Protein alpha Subunits, Gq-G11Phospholipase C beta

Identifiers

PMID31825720
PMCPMC7202066
OpenAlexW2995630731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.