ArticleJournal of neurophysiology2020
Transcranial alternating current stimulation attenuates BOLD adaptation and increases functional connectivity.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Dose-response in modulating brain function with transcranial direct current stimulation: From local to network levels.PLoS computational biology · 2023Trial
- Individual differences in neuroanatomy and neurophysiology predict effects of transcranial alternating current stimulation.Brain stimulationTrial
- Dissociating mechanisms of spatial suppression and summation in human visual cortical regions MT/V5: a transcranial Direct Current Stimulation (tDCS) study and clinical implications.International review of psychiatry (Abingdon, England) · 2026Article
- α -tACS Modulates Reward-Dependent Pupil Responses and Corticostriatal Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Transcranial alternating current stimulation over left DLPFC modulates feedback processing: a simultaneous tACS-fMRI study.Translational psychiatry · 2026Article
- Individual alpha frequency tACS reduces static functional connectivity across the default mode network.Frontiers in human neuroscience · 2025Article
- Direct current stimulation modulates prefrontal cell activity and behaviour without inducing seizure-like firing.Brain : a journal of neurology · 2024Article
- Neural Network Connectivity Following Opioid Dependence is Altered by a Common Genetic Variant in the µ-Opioid Receptor,The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A Review on Motor Imagery with Transcranial Alternating Current Stimulation: Bridging Motor and Cognitive Welfare for Patient Rehabilitation.Brain sciences · 2023Review
- Noninvasive Brain Stimulation for Neurorehabilitation in Post-Stroke Patients.Brain sciences · 2023Review
- Alpha oscillatory activity is causally linked to working memory retention.PLoS biology · 2023Article
- Mechanisms of Action of Noninvasive Brain Stimulation with Weak Non-Constant Current Stimulation Approaches.Iranian journal of psychiatry · 2023Article
- Transcranial stimulation of alpha oscillations up-regulates the default mode network.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Predictive Value of Individual Electric Field Modeling for Transcranial Alternating Current Stimulation Induced Brain Modulation.Frontiers in cellular neuroscience · 2022Article
- Toward integrative approaches to study the causal role of neural oscillations via transcranial electrical stimulation.Nature communications · 2021Review
- Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Removal of the Sinusoidal Transorbital Alternating Current Stimulation Artifact From Simultaneous EEG Recordings: Effects of Simple Moving Average Parameters.Frontiers in neuroscience · 2020Article
- Dose-response relationships in transcranial brain stimulation: Physics, physiology and mechanism.Brain stimulationReview
- Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transcranial alternating current stimulation (tACS) is used as a noninvasive tool for cognitive enhancement and clinical applications. The physiological effects of tACS, however, are complex and poorly understood. Most studies of tACS focus on its ability to entrain brain oscillations, but our behavioral results in humans and extracellular recordings in nonhuman primates support the view that tACS at 10 Hz also affects brain function by reducing sensory adaptation. Our primary goal in the present study is to test this hypothesis using blood oxygen level-dependent (BOLD) imaging in human subjects. Using concurrent functional magnetic resonance imaging (fMRI) and tACS, and a motion adaptation paradigm developed to quantify BOLD adaptation, we show that tACS significantly attenuates adaptation in the human motion area (hMT+). In addition, an exploratory analysis shows that tACS increases functional connectivity of the stimulated hMT+ with the rest of the brain and the dorsal attention network in particular. Based on field estimates from individualized head models, we relate these changes to the strength of tACS-induced electric fields. Specifically, we report that functional connectivity (between hMT+ and any other region of interest) increases in proportion to the field strength in the region of interest. These findings add support for the claim that weak 10-Hz currents applied to the scalp modulate both local and global measures of brain activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.