Evidence map›Paper›PMID 31825472›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2020

Decreases in the Late Positive Potential to Alcohol Images Among Alcohol Treatment Seekers Following Mindfulness-Based Relapse Prevention.

Darin R Brown, Trevor C J Jackson, Eric D Claus, Victoria R Votaw, Elena R Stein, Charles S H Robinson, Adam D Wilson, Emma Brandt, Violet Fratzke, Vincent P Clark and 1 more

Registry-linked trialOpen access · bronzeAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02861807 (Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02861807 nacompletednot on this map

Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking: Efficacy and Mechanisms of Change

TypeinterventionalSponsorUniversity of New MexicoRan2016 to 2018Enrolled84ConditionsAlcohol Drinking, Alcohol Intoxication, AlcoholismArmsBrain stimulation with mindfulness-based relapse prevention
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Darin R BrownDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Trevor C J JacksonDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Eric D ClausDepartment of Translational Neuroscience, Mind Research Network of the Lovelace Biomedical Research Institute, 1101 Yale Blvd NE, Albuquerque, NM 87106, USA.
Victoria R VotawDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Elena R SteinDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Charles S H RobinsonDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Adam D WilsonDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Emma BrandtDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Violet FratzkeDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Vincent P ClarkDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
Katie WitkiewitzDepartment of Psychology, University of New Mexico, MSC 03-2220, Albuquerque, NM 87131, USA.
University of New Mexico · USMind Research Network · US

Funding

Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking: Efficacy and Mechanisms of ChangeR21AA024926 · NIAAA · UNIVERSITY OF NEW MEXICO · PI WITKIEWITZ, KATIE A · 2016 to 2017
$409k
NIAAA NIH HHS R21 AA024926
6 · The paper itself

Abstract

aimHeightened craving among individuals with alcohol use disorder (AUD) has been attributed to a hypersensitivity to alcohol cues in attentional brain networks. Active mindfulness training has been shown to help improve attentional control. Here, we examined alcohol cue-related hypersensitivity among individuals with AUD who received rolling group mindfulness-based relapse prevention (MBRP) in combination with transcranial direct current stimulation (tDCS), over right inferior frontal gyrus.

methodsParticipants (n = 68) viewed a series of emotionally negative, emotionally neutral and alcohol-related images. Following image presentation, participants were asked to rate their level of craving for the alcohol cues, and their level of negative affect evoked by neutral and negative cues. During the task, electroencephalogram (EEG) was recorded to capture an event-related component shown to relate to emotionally salient stimuli: the late positive potential (LPP). Participants who completed a follow-up EEG (n = 37) performed the task a second time after up to eight sessions of MBRP coupled with active or sham tDCS.

resultsWe found that both craving ratings and the LPP significantly decreased in response to alcohol cues from pre- to post-treatment, but not for other image cues. The magnitude of alcohol image craving reductions was associated with the number of MBRP group sessions attended. Active tDCS was not associated with craving ratings, but it was associated with greater LPP amplitudes across image types.

conclusionsTaken together, these results suggest that disruption of alcohol-cue hypersensitivity in people with AUD may be a target mechanism of MBRP.

Indexed as

MindfulnessTranscranial Direct Current StimulationAdultAffectAgedAlcoholismCombined Modality TherapyCravingCuesElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedPhotic Stimulation

Identifiers

PMID31825472
PMCPMC13368806
OpenAlexW2995273263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.