ArticleeLife2019
Agonist-specific voltage-dependent gating of lysosomal two-pore Na
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In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Endolysosomal two-pore channels regulate a conserved entry pathway for enteroviruses.The Journal of general virology · 2026Article
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- The Two-Pore Channel 2 in Human Physiology and Diseases: Functional Characterisation and Pharmacology.International journal of molecular sciences · 2025Review
- Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.The Journal of cell biology · 2025Article
- Lysosomal Channels as New Molecular Targets in the Pharmacological Therapy of Neurodegenerative DiseasesCurrent neuropharmacology · 2025Review
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist.Structure (London, England : 1993) · 2024Article
- The ion channels of endomembranes.Physiological reviews · 2024Review
- Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Convergent activation of CaScience signaling · 2023Article
- Improved approaches to channel capacity estimation discover compromised GPCR signaling in diverse cancer cells.iScience · 2023Article
- Conformational rearrangements in the second voltage sensor domain switch PIPProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels.Handbook of experimental pharmacology · 2023Article
- Lysosomal Potassium Channels.Handbook of experimental pharmacology · 2023Review
- NAADP-Mediated CaHandbook of experimental pharmacology · 2023Article
- Lysosomal solute and water transport.The Journal of cell biology · 2022Review
- TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann-Pick type C1, and Batten disease.EMBO molecular medicine · 2022Article
- COVID-19 metabolism: Mechanisms and therapeutic targets.MedComm · 2022Review
- Two-pore channels: going with the flows.Biochemical Society transactions · 2022Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Xiaoli Zhang *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-0507-6317
Wei Chen *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-2794-2407
Ping Li *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Raul CalvoNational Center for Advancing Translational Sciences (NCATS), Medical Center Drive, Rockville, United States.
Noel SouthallNational Center for Advancing Translational Sciences (NCATS), Medical Center Drive, Rockville, United States.ORCID 0000-0003-4500-880X
Xin HuNational Center for Advancing Translational Sciences (NCATS), Medical Center Drive, Rockville, United States.
Melanie Bryant-GenevierNational Center for Advancing Translational Sciences (NCATS), Medical Center Drive, Rockville, United States.
Xinghua FengCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Qi GengDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Chenlang GaoDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Meimei YangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Kaiyuan TangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.
Marc FerrerNational Center for Advancing Translational Sciences (NCATS), Medical Center Drive, Rockville, United States.
Juan Jose MaruganNational Center for Advancing Translational Sciences (NCATS), Medical Center Drive, Rockville, United States.ORCID 0000-0002-3951-7061
Haoxing XuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID 0000-0003-3561-4654
University of Michigan · USNational Center for Advancing Translational Sciences · USHarbin Medical University · CNZhejiang University of Technology · CN
Funding
The Mucolipin TRP Ion ChannelsR01NS062792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, HAOXING · 2009 to 2018
$3.3MIon channels in the tubulovesiclesR01DK115474 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AKAABOUNE, MOHAMMED, DU, WANLU · 2018 to 2022
$1.4MNIDDK NIH HHS DK115474NIDDK NIH HHS R01 DK115474NINDS NIH HHS NS062792NINDS NIH HHS R01 NS062792
Abstract
Mammalian two-pore-channels (TPC1, 2;
Indexed as
AnimalsAntidepressive Agents, TricyclicCalcium Channel AgonistsCalcium ChannelsCell LineDNA Mutational AnalysisHumansLysosomesMutagenesis, Site-DirectedPhosphatidylinositol PhosphatesTwo-Pore ChannelsAntidepressive Agents, TricyclicCalcium Channel AgonistsCalcium Channelsphosphatidylinositol 3,5-diphosphatePhosphatidylinositol PhosphatesTPCN1 protein, humanTPCN2 protein, humanTwo-Pore Channelslysosomal Na+ channelslysosomal two-pore channelsneurosciencenonetri-cyclic antidepressantswhole-endolysosome patch clamp
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.